6-nitro-5-(piperidin-1-yl)-1H-benzimidazole-2-thiol | 1319671-85-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 6-nitro-5-(piperidin-1-yl)-1H-benzimidazole-2-thiol
• 英文别名: 5-Nitro-6-piperidin-1-yl-1,3-dihydrobenzimidazole-2-thione；5-nitro-6-piperidin-1-yl-1,3-dihydrobenzimidazole-2-thione
• CAS: 1319671-85-6
• 化学式: C₁₂H₁₄N₄O₂S
• 分子量: 278.335
• InChiKey: NWYYGCUKXINQHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-nitro-5-(piperidin-1-yl)-1H-benzimidazole-2-thiol 在 potassium carbonate 、 potassium hydrogencarbonate 、 间氯过氧苯甲酸 、 potassium iodide 作用下， 以 乙醇 、 二氯甲烷 、 丙酮 为溶剂， 反应 4.25h， 生成 2-[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl-6-nitro-5-(piperidin-1-yl)-1H-benzimidazole
  参考文献：
  名称：

  A reverse method for diversity introduction of benzimidazole to synthesize H+/K+-ATP enzyme inhibitors

  摘要：

  A series of 2-[(2-pyridylmethyl)sulfinyl]benzimidazole derivatives were synthesized via a solution phase synthetic route using a reversal method of diversity introduction. Using this synthetic strategy, we obtained two key intermediates (4-A and 4-B) simultaneously, which allows us to introduce diversity points onto the benzimidazole part of the final product under reliable reaction conditions to identify potent H+/K+-ATP enzyme inhibitors. Compound 141 (IC50 = 1.6 x 10 (5) M) was comparable with H+/K+-ATP enzyme inhibitor in vitro. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.080
• 作为产物：
  描述：

  2,4-二硝基-5-氟苯胺 在 sodium hydrogensulfide 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 11.0h， 生成 6-nitro-5-(piperidin-1-yl)-1H-benzimidazole-2-thiol
  参考文献：
  名称：

  A reverse method for diversity introduction of benzimidazole to synthesize H+/K+-ATP enzyme inhibitors

  摘要：

  A series of 2-[(2-pyridylmethyl)sulfinyl]benzimidazole derivatives were synthesized via a solution phase synthetic route using a reversal method of diversity introduction. Using this synthetic strategy, we obtained two key intermediates (4-A and 4-B) simultaneously, which allows us to introduce diversity points onto the benzimidazole part of the final product under reliable reaction conditions to identify potent H+/K+-ATP enzyme inhibitors. Compound 141 (IC50 = 1.6 x 10 (5) M) was comparable with H+/K+-ATP enzyme inhibitor in vitro. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.080

文献信息

• A reverse method for diversity introduction of benzimidazole to synthesize H+/K+-ATP enzyme inhibitors
  作者：Yu Yan、Zijie Liu、Jianjun Zhang、Ruiming Xu、Xiao Hu、Gang Liu

  DOI：10.1016/j.bmcl.2011.05.080

  日期：2011.7

  A series of 2-[(2-pyridylmethyl)sulfinyl]benzimidazole derivatives were synthesized via a solution phase synthetic route using a reversal method of diversity introduction. Using this synthetic strategy, we obtained two key intermediates (4-A and 4-B) simultaneously, which allows us to introduce diversity points onto the benzimidazole part of the final product under reliable reaction conditions to identify potent H+/K+-ATP enzyme inhibitors. Compound 141 (IC50 = 1.6 x 10 (5) M) was comparable with H+/K+-ATP enzyme inhibitor in vitro. (C) 2011 Elsevier Ltd. All rights reserved.