(+)-4-exo-Methylbicyclo<3.3.0>oct-2-en-8-endo-ol | 88915-78-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (+)-4-exo-Methylbicyclo<3.3.0>oct-2-en-8-endo-ol
• 英文别名: (1R,3aR,4S,6aS)-4-methyl-1,2,3,3a,4,6a-hexahydropentalen-1-ol
• CAS: 88915-78-0
• 化学式: C₉H₁₄O
• 分子量: 138.21
• InChiKey: SRADZQMVYPWOOX-UYXSQOIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (+)-4-exo-Methylbicyclo<3.3.0>oct-2-en-8-endo-ol 、 对甲苯磺酰氯 以 吡啶 为溶剂， 反应 16.0h， 以85%的产率得到(+)-4-exo-Methylbicyclo<3.3.0>oct-2-en-8-endo-yl p-Toluenesulfonate
  参考文献：
  名称：

  Total syntheses with tricyclooctanone building blocks. Synthesis of iridodial

  摘要：

  DOI：

  10.1021/jo00181a001
• 作为产物：
  描述：

  (+)-4-exo-Methylbicyclo<3.3.0>oct-2-en-8-endo-yl Acetate 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 0.25h， 以98%的产率得到(+)-4-exo-Methylbicyclo<3.3.0>oct-2-en-8-endo-ol
  参考文献：
  名称：

  Total syntheses with tricyclooctanone building blocks. Synthesis of iridodial

  摘要：

  DOI：

  10.1021/jo00181a001

文献信息

• SYNTHESIS OF BICYCLIC COMPOUNDS AND METHOD FOR THEIR USE AS THERAPEUTIC AGENTS
  申请人：Wulff Jeremy E.

  公开号：US20130210904A1

  公开（公告）日：2013-08-15

  Disclosed embodiments concern the synthesis and use of therapeutic compounds that for treating emerging flu strains and minimizing resistance to such strains. Methods for making the disclosed compounds concern using a base-mediated addition/cyclization sequence followed by functional group manipulation to develop functionalized compounds that can target neuraminidase, which makes them ideal candidates for treating influenza. Pharmaceutical compositions comprising the therapeutic compounds and biologically-acceptable materials are also described. Methods of inhibiting neuraminidase in subjects that are suspected of containing neuraminidase are also described. The use of metabolites of the disclosed compounds can also be used in diagnostic assays for therapeutic dosing of the disclosed compounds.
• US8883846B2
  申请人：——

  公开号：US8883846B2

  公开（公告）日：2014-11-11