2-pentyloxy-ethylamine | 89979-74-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-pentyloxy-ethylamine
• 英文别名: 2-Pentoxyethanamine
• CAS: 89979-74-8
• 化学式: C₇H₁₇NO
• 分子量: 131.218
• InChiKey: RFONZLGCNSSOMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-pentyloxy-ethylamine 生成 1-(2-diazo-ethoxy)-pentane
  参考文献：
  名称：

  Grot,C. et al., Justus Liebigs Annalen der Chemie, 1964, vol. 679, p. 42 - 50

  摘要：

  DOI：
• 作为产物：
  描述：

  乙烯亚胺 、 戊醇 生成 2-pentyloxy-ethylamine
  参考文献：
  名称：

  Harder,U. et al., Chemische Berichte, 1964, vol. 97, p. 510 - 519

  摘要：

  DOI：

文献信息

• Synthesis and Optimization of a New Family of Type 3 17β-Hydroxysteroid Dehydrogenase Inhibitors by Parallel Liquid-Phase Chemistry
  作者：René Maltais、Van Luu-The、Donald Poirier

  DOI：10.1021/jm010286y

  日期：2002.1.1

  (D) of 3-carbamate-ADT derivatives (25 members) using the efficient parallel liquid-phase method III, which allowed the synthesis of more rigid molecules with two levels of molecular diversity (R(1)/R(2) and R(3)) in the local area occupied by the adamantane group of C-7-3. Interestingly, one of the most potent inhibitors of library D, the 3R-spiro-[3'-[3' '-N-morpholino-2' '-(3' "-cyclopentyl-prop

  3型17β-羟基类固醇脱氢酶（17 beta-HSD）将4-雄烯3,17-二酮（Delta（4）-二酮）转化为雄激素睾丸激素。为了生产这种关键的类固醇生成酶的有效抑制剂，我们以较高的收率和平均高效液相色谱（HPLC）纯度为92-94％进行了3beta-取代的雄甾酮（ADT）文库（AD）的并行液相合成。使用并行液相法合成了3个β-氨基甲基ADT衍生物（168个成员）的第一文库（A），其中包括酰胺上的两个分子多样性水平（R（1）和R（2））（方法I）比传统的化学方法花费的时间更少。库A的筛选显示，R（1）（5-8个碳）处的疏水链相对较小，R（2）（1-4个碳）处的疏水取代基较小，提供了最有效的抑制剂。根据这些抑制结果，使用基于清除剂树脂和液相平行化学的改进方法，在很短的时间内生成了3个β-氨基甲基-ADT衍生物（56个成员）的第二个文库（B）。库B比库A产生了更强的抑制剂，并提供了有用的结构-
• AMINOETHYLATION PROCESS HAVING IMPROVED YIELD OF ARYLOXYALKYLENE AMINE COMPOUNDS AND REDUCED UREA BY-PRODUCTS
  申请人：McDougall Patrick J.

  公开号：US20140073814A1

  公开（公告）日：2014-03-13

  Disclosed is a process for preparing an aryloxyalkylene amine compound via an aminoethylation reaction comprising: a) reacting an aromatic hydroxyl compound in the presence of a basic catalyst with a 2-oxazolidinone compound of the formula II to form an intermediate reaction product; wherein R 3 is selected from the group consisting of hydrogen or lower alkyl having 1 to 6 carbon atoms, R 4 is selected from the group consisting of hydrogen, straight or branched chain alkyl having from one to six carbon atoms, phenyl, alkaryl, or arylalkyl; and b) reacting the intermediate product of step a) with a polyalkylene polyamine.

  揭示了一种通过氨基乙基化反应制备芳基氧基烷胺化合物的过程，包括：a)在碱性催化剂存在下，将芳香羟基化合物与式II的2-噁唑烷酮化合物反应，形成中间反应产物；其中R3选自氢或1至6个碳原子的较低烷基，R4选自氢、一元或分支链烷基（含1至6个碳原子）、苯基、烷基芳基或芳基烷基；b)将步骤a）中间产物与聚烷基聚胺反应。
• PROCESS FOR ALKYLATING TRIAZINE DERIVATIVE
  申请人：NISSAN CHEMICAL INDUSTRIES, LIMITED

  公开号：EP0760369A1

  公开（公告）日：1997-03-05

  The object of the present invention is to provide a method for producing substituted-1,3,5-triazine derivatives at high yield, in which at least one of carbon atoms in the ring thereof is substituted by a secondary amine group having at leat one of alkyl groups. The method of the present invention is a method for alkylation of 1,3,5-triazine derivatives, characterized by reacting 1,3,5-triazine derivatives (melamines, melamine derivatives, various kinds of guanaminde derivatives, etc.) which has at least one or more amino groups or mono-substituted amino groups on carbon atom of the ring thereof, with aldehydes or ketones alcohols in the presence of a catalyst of a metal of group VII and/or group VIII in the periodic table and a hydrogen-containing gas to alkylate said at least one of amino groups or mono-substituted amino groups. These derivatives are widely used as intermediates of fine chemicals such as agricultural chemicals, medications, dyestuffs, paints and the like and are widely used resin materials and as flame-retardant materials.

  本发明的目的是提供一种高产率生产取代的-1,3,5-三嗪衍生物的方法，在这种衍生物中，其环上至少有一个碳原子被至少有一个烷基的仲胺基取代。 本发明的方法是 1,3,5-三嗪衍生物的烷基化方法，其特征是将 1,3,5-三嗪衍生物（三聚氰胺、三聚氰胺衍生物、各种胍衍生物等）与至少具有一个或多个烷基的 1,3,5-三嗪衍生物（三聚氰胺、三聚氰胺衍生物、各种胍衍生物等）反应。其特征是：在元素周期表中第 VII 族和/或 VIII 族金属和含氢气体催化剂的存在下，将环的碳原子上至少有一个或多个氨基或单取代氨基的 1,3,5-三嗪衍生物（三聚氰胺、三聚氰胺衍生物、各种鸟苷酸衍生物等）与醛或酮醇反应，使上述至少一个氨基或单取代氨基烷基化。 这些衍生物被广泛用作精细化工产品的中间体，如农药、药物、染料、油漆等，也被广泛用作树脂材料和阻燃材料。
• Process for preparing 1,3-disubstituted urea
  申请人：SUMIKA FINE CHEMICALS Co., Ltd.

  公开号：EP0846679A2

  公开（公告）日：1998-06-10

  Process for preparing 1,3-disubstituted urea of the formula: wherein R5 is the same as or different from R6, and each of R5 and R6 is independently linear or branched, alkyl of 1-20 carbon atoms, alkenyl group having 2 to 20 carbon atoms or alkynyl group having 2 to 20 carbon atoms, which may have phenoxy, alkoxy of 1-13 carbon atoms, monocycloalkyl of 3-8 carbon atoms, bicycloalkyl of 6-12 carbon atoms, aryl of 6-13 carbon atoms, furyl, pyridyl, or aralkyl of 7-20 carbon atoms, comprising reacting cyclic carbonic acid ester with an amine using alkali metal alkoxide or trialkylamine as base, in safety and high yield.

  制备式 1，3-二取代脲的工艺： 其中 R5 与 R6 相同或不同，R5 和 R6 各自独立地为 1-20 个碳原子的直链或支链烷基、具有 2-20 个碳原子的烯基或具有 2-20 个碳原子的炔基，它们可以具有苯氧基、1-13 个碳原子的烷氧基、3-8 个碳原子的单环烷基、6-12 个碳原子的双环烷基、6-13 个碳原子的芳基、3-8 个碳原子的单环烷基、6-12 个碳原子的双环烷基、6-13 个碳原子的芳基、7-20 个碳原子的呋喃基、吡啶基或芳烷基，包括以碱金属氧化物或三烷基胺为碱，使环状碳酸酯与胺反应，安全且收率高。
• METHODS FOR MODIFYING 1,3,5-TRIAZINE DERIVATIVES
  申请人：NISSAN CHEMICAL INDUSTRIES, LIMITED

  公开号：EP0882720A1

  公开（公告）日：1998-12-09

  A method for modifying 1,3,5-triazine derivatives characterized by reacting a 1,3,5-triazine derivative having at least one amino or monosubstituted amino group on any of the ring carbon atoms with an alcohol by heating in the presence of a metallic catalyst and hydrogen to thereby introduce an alkyl or alkenyl group into each amino or monosubstituted amino group; another method for modifying 1,3,5-triazine derivatives characterized by reacting a 1,3,5-triazine derivative having at least one amino or monosubstituted amino group on any of the ring carbon atoms with a dihydric alcohol by heating in the presence of a metallic catalyst and hydrogen to thereby introduce a hydroxylated alkyl group into each amino or monosubstituted amino group; and 1,3,5-triazine derivatives obtained by the methods. The various modified substituted 1,3,5-triazine derivatives thus produced are generally obtained as a mixture. These derivatives can be isolated as high-purity compounds by a general separation method for organic compounds, and the compounds are usable in the various applications mentioned in the specification. According to applications (for example, use as modifier additives, in particular a flame-retardant and a plasticizer for resins), the reaction mixture can be used as it is without being separated. Many of the substituted triazine derivatives obtained have been relatively difficult to synthesize or expensive. Since many of the derivatives are interesting with respect to their physical properties, e.g., solubility in water and in various organic solvents, high-temp. stability, melting point, boiling point, and basicity, they are thought to have a wider range of applications than conventional ones.

  一种改性 1，3，5-三嗪衍生物的方法，其特征在于在金属催化剂和氢的存在下，通过加热使任一环碳原子上具有至少一个氨基或单取代氨基的 1，3，5-三嗪衍生物与醇反应，从而在每个氨基或单取代氨基中引入一个烷基或烯基；另一种改性 1,3,5-三嗪衍生物的方法，其特征在于在金属催化剂和氢气存在下，使任一环碳原子上具有至少一个氨基或单取代氨基的 1,3,5-三嗪衍生物与二元醇反应，从而在每个氨基或单取代氨基中引入羟基烷基；以及通过上述方法获得的 1,3,5-三嗪衍生物。这样制得的各种改性取代的 1,3,5-三嗪衍生物通常以混合物的形式获得。这些衍生物可作为高纯度化合物通过有机化合物的一般分离方法分离出来，这些化合物可用于说明书中提到的各种应用中。根据用途（例如用作改性添加剂，特别是阻燃剂和树脂增塑剂），反应混合物可以不经分离直接使用。所获得的许多取代三嗪衍生物都比较难以合成或价格昂贵。由于许多衍生物在物理性质（如在水和各种有机溶剂中的溶解性、高温稳定性、熔点、沸点和碱性）方面都很有趣，因此它们被认为比传统的衍生物具有更广泛的用途。