((2S,3S,4S,5R,6R)-2,4,5-Tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-acetic acid | 705951-27-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ((2S,3S,4S,5R,6R)-2,4,5-Tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-acetic acid
• CAS: 705951-27-5
• 化学式: C₃₆H₃₈O₈
• 分子量: 598.693
• InChiKey: AJCDAIPVQHMDOC-KOABPKSUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.79
• 重原子数：
  44.0
• 可旋转键数：
  16.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  92.68
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  ((2S,3S,4S,5R,6R)-2,4,5-Tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-acetic acid 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries

  摘要：

  A focused library of novel, sulfated glycoconjugates was synthesized by utilizing carbohydrate-derived blocks in the four-component Ugi condensation. Library members comprise a sulfated monosaccharide linked by various spacers to either in aromatic or monosulfated moiety, or a second sulfated monosaccharide. The affinities of these heparan sulfate (HS) mimetics for the HS-binding fibroblast growth factors FGF-1 and FGF-2 were measured via a surface plasmon resonance solution affinity assay. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.017
• 作为产物：
  描述：

  ((2S,3S,4S,5R,6R)-2,4,5-Tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-acetic acid tert-butyl ester 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 ((2S,3S,4S,5R,6R)-2,4,5-Tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-acetic acid
  参考文献：
  名称：

  Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries

  摘要：

  A focused library of novel, sulfated glycoconjugates was synthesized by utilizing carbohydrate-derived blocks in the four-component Ugi condensation. Library members comprise a sulfated monosaccharide linked by various spacers to either in aromatic or monosulfated moiety, or a second sulfated monosaccharide. The affinities of these heparan sulfate (HS) mimetics for the HS-binding fibroblast growth factors FGF-1 and FGF-2 were measured via a surface plasmon resonance solution affinity assay. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.017