1-(4-(trifluoromethyl)phenyl)-1,2-dihydrobenzo[g]quinoline-5,10-dione | 1445727-35-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(4-(trifluoromethyl)phenyl)-1,2-dihydrobenzo[g]quinoline-5,10-dione
• 英文别名: 1-[4-(trifluoromethyl)phenyl]-2H-benzo[g]quinoline-5,10-dione
• CAS: 1445727-35-4
• 化学式: C₂₀H₁₂F₃NO₂
• 分子量: 355.316
• InChiKey: ROUACMVQAXSRQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-((4-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione 在 四丁基溴化铵 、 copper(II) bis(trifluoromethanesulfonate) 、 sodium hydroxide 作用下， 以 水 、 甲苯 为溶剂， 反应 2.0h， 生成 1-(4-(trifluoromethyl)phenyl)-1,2-dihydrobenzo[g]quinoline-5,10-dione
  参考文献：
  名称：

  An expedient synthesis of 1,2-dihydrobenzo[g]quinoline-5,10-diones via copper(II) triflate-catalyzed intramolecular cyclization of N-propargylaminonaphthoquinones

  摘要：

  An expedient synthesis of a series of 1,2-dihydrobenzo[g]quinoline-5,10-diones in good yields has been accomplished via three-component one pot sequential reactions of 2-hydroxynaphthalene-1,4-dione, substituted anilines and propargyl as well as 3-ethylpropargyl bromides furnishing N-propargylaminonaphthoquinones, and their concomitant copper(II) triflate-catalyzed intramolecular 6-endo-dig cyclization. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.125

文献信息

• An expedient synthesis of 1,2-dihydrobenzo[g]quinoline-5,10-diones via copper(II) triflate-catalyzed intramolecular cyclization of N-propargylaminonaphthoquinones
  作者：Balasubramanian Devi Bala、Sivasubramanian Muthusaravanan、Subbu Perumal

  DOI：10.1016/j.tetlet.2013.04.125

  日期：2013.7

  An expedient synthesis of a series of 1,2-dihydrobenzo[g]quinoline-5,10-diones in good yields has been accomplished via three-component one pot sequential reactions of 2-hydroxynaphthalene-1,4-dione, substituted anilines and propargyl as well as 3-ethylpropargyl bromides furnishing N-propargylaminonaphthoquinones, and their concomitant copper(II) triflate-catalyzed intramolecular 6-endo-dig cyclization. (C) 2013 Elsevier Ltd. All rights reserved.