Nostocyclophane B heptaacetate | 134237-86-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Nostocyclophane B heptaacetate
• 英文别名: [(2R,3R,4S,5R,6S)-3,4,5-triacetyloxy-6-[[(2R,4R,8S,13R,15R,19S)-21,24,26-triacetyloxy-8,19-dibutyl-4,15-dichloro-2,13-dimethoxy-10-tricyclo[18.2.2.29,12]hexacosa-1(22),9,11,20,23,25-hexaenyl]oxy]oxan-2-yl]methyl acetate
• CAS: 134237-86-8
• 化学式: C₅₆H₇₈Cl₂O₁₈
• 分子量: 1110.13
• InChiKey: UUBGXHDJQYFXPI-IQIGBMSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.6
• 重原子数：
  76
• 可旋转键数：
  25
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  221
• 氢给体数：
  0
• 氢受体数：
  18

反应信息

• 作为产物：
  描述：

  乙酸酐 、 Nostocyclophane D 9-O-(2,3,4,6-tetra-O-acetyl)-β-D-glucopyranoside 在 吡啶 作用下， 以83.4%的产率得到Nostocyclophane B heptaacetate
  参考文献：
  名称：

  Structures of nostocyclophanes A-D

  摘要：

  Nostocyclophanes A-D are the cytotoxins associated with the blue-green alga Nostoc linckia (Roth) Bornet ex Bornet & Flahault (UTEX B1932). The gross structures of these [7.7]paracyclophanes have been elucidated by mass and NMR spectral analyses and the relative and absolute stereochemistry of nostocyclophane D determined by X-ray crystallography. Since the CD spectra of the four compounds are essentially identical, nostocyclophanes A-D are proposed to have the same stereochemistry. The sugar unit in nostocyclophanes A and B has been shown to be D-glucose by semisynthesis of nostocyclophane B 9-O-(2,3,4,6-tetra-O-acetyl)-beta-D-glucopyranoside from nostocyclophanes B and D.

  DOI：

  10.1021/jo00014a008

文献信息

• CHEN, JIAN LU;MOORE, RICHARD E.;PATTERSON, GREGORY M. L., J. ORG. CHEM., 56,(1991) N4, C. 4360-4364
  作者：CHEN, JIAN LU、MOORE, RICHARD E.、PATTERSON, GREGORY M. L.

  DOI：——

  日期：——