[(2R,3R,4S,5R,6S)-3-hydroxy-6-methoxy-4,5-bis(phenylmethoxy)oxan-2-yl]methyl 3,5-dinitro-2-[(2S,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxybenzoate | 330184-05-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3R,4S,5R,6S)-3-hydroxy-6-methoxy-4,5-bis(phenylmethoxy)oxan-2-yl]methyl 3,5-dinitro-2-[(2S,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxybenzoate
• CAS: 330184-05-9
• 化学式: C₆₂H₆₂N₂O₁₇
• 分子量: 1107.18
• InChiKey: ZEDAUCBNIYOZDW-QQNFYBSHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  81
• 可旋转键数：
  26
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  231
• 氢给体数：
  1
• 氢受体数：
  17

反应信息

• 作为产物：
  描述：

  2-氟-3,5-二硝基苯甲酸 在 1,4-二甲基哌嗪 、 草酰氯 、 lithium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 19.25h， 生成 [(2R,3R,4S,5R,6S)-3-hydroxy-6-methoxy-4,5-bis(phenylmethoxy)oxan-2-yl]methyl 3,5-dinitro-2-[(2S,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxybenzoate
  参考文献：
  名称：

  Intramolecular Glycosylation under Neutral Conditions for Synthesis of 1,4-Linked Disaccharides

  摘要：

  [GRAPHICS]A new method for intramolecular glycosylation, in which the donor and acceptor were linked via a 3,4-dinitrosalicylic acid derivative, was developed. Simply dissolving the tethered glycoside in CH3NO2 and warming to 40-60 degreesC led to formation of 1,4-linked disaccharides under neutral, hence, exceptionally mild, conditions.

  DOI：

  10.1021/ol006988j

文献信息

• Intramolecular Glycosylation under Neutral Conditions for Synthesis of 1,4-Linked Disaccharides
  作者：Jane B. Laursen、Lars Petersen、Knud J. Jensen

  DOI：10.1021/ol006988j

  日期：2001.3.1

  [GRAPHICS]A new method for intramolecular glycosylation, in which the donor and acceptor were linked via a 3,4-dinitrosalicylic acid derivative, was developed. Simply dissolving the tethered glycoside in CH3NO2 and warming to 40-60 degreesC led to formation of 1,4-linked disaccharides under neutral, hence, exceptionally mild, conditions.