9.15-Octadecadiensaeure | 18402-92-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 9.15-Octadecadiensaeure
• 英文别名: (9Z,15Z)-octadeca-9,15-dienoic acid
• CAS: 18402-92-1
• 化学式: C₁₈H₃₂O₂
• 分子量: 280.451
• InChiKey: AWGFYZFANDHELM-RTAKVZRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  9.15-Octadecadiensaeure 、 (S)-4-(dimethylamino)butane-1,2-diol hydrochloride 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 生成 [(2S)-4-(dimethylamino)-2-[(9Z,15Z)-octadeca-9,15-dienoyl]oxybutyl] (9Z,15Z)-octadeca-9,15-dienoate
  参考文献：
  名称：

  [EN] LIPID NANOPARTICLES FOR DELIVERY OF NUCLEIC ACIDS AND METHODS OF USE THEREOF
  [FR] NANOPARTICULES LIPIDIQUES POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  The present disclosure provides for improved compositions of ionizable lipid nanoparticles for the delivery of therapeutic nucleic acids to cells. Anionic phospholipids, including phosphatidyl serine and phosphatidylglycerol are included in the lipid nanoparticles to increase the transfection efficiency in human dendritic cells. The further incorporation of mono-unsaturated alkyl chain analogs in dimethylaminopropyl-di oxolane or heterocyclic ketal ionizable lipids in the formulation demonstrated high levels of transfection in human dendritic cells, compared to other ionizable lipids in the same family, and demonstrated good stability to oxidative damage. Finally, the use of an ammonium salt of phosphatidylserine allows for the efficient production of PS-targeted LNPs.

  公开号：

  WO2023230587A2
• 作为产物：
  描述：

  2-(9-癸炔-1-基氧基)四氢-2H-吡喃 在 Lindlar's catalyst 吡啶 、 六甲基磷酰三胺 、 正丁基锂 、 jones reagent 、 氢气 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 丙酮 为溶剂， 反应 0.25h， 生成 9.15-Octadecadiensaeure
  参考文献：
  名称：

  Gruiec, Regine; Noiret, Nicolas; Patin, Henri, Bulletin de la Societe Chimique de France, 1994, vol. 131, # 6, p. 699 - 705

  摘要：

  DOI：

文献信息

• COATING COMPOSITION COMPRISING AUTOXIDISABLE COMPONENT
  申请人：DSM IP Assets B.V.

  公开号：EP2262860A1

  公开（公告）日：2010-12-22
• STABLE CYCLOSPORINE CONTAINING OPHTHALMIC EMULSION FOR TREATING DRY EYES
  申请人：Yu Zhi-Jian

  公开号：US20120093894A1

  公开（公告）日：2012-04-19

  Disclosed herein are stable oil-in-water emulsion ophthalmic topical liquid compositions having an average particle size less than 1 μm including at least one plant-derived oil other than castor oil wherein the oil comprises only aliphatic side chains free of polar pendent groups. The oil-in-water emulsion ophthalmic topical liquid compositions also include a hydrophilic surfactant having an HLB value between approximately 10 and 14, a vegetable oil-derived hydrophobic non-co-block surfactant having unsaturated side chains that contain less than four oxygen atoms having an HLB value between approximately 4 and 6 and is a liquid at room temperature. The oil-in-water emulsion ophthalmic topical liquid compositions disclosed herein can further include an amount of cyclosporine A or polyphenol in an amount effective to relieve dry eye symptoms.
• PROCESS FOR MAKING HIGH-PERFORMANCE POLYETHYLENE MULTIFILAMENT YARN
  申请人：VAN CASTEREN Ilse

  公开号：US20140004351A1

  公开（公告）日：2014-01-02

  An aqueous solution coating composition comprising an autoxidisable polyvinyl polymer having ≧20% of fatty acid residue by weight of polymer; T g from −60 to +15° C.; acid value of 15 to 75 mg KOH/g, M w from 2500 to 100000 g/mol; polydispersity ≦30, said composition having ≦25% co-solvent by weight of solids, ≧30% solids by weight of composition; said composition when in the form of a coating having a telegraphing value defined as the difference in gloss at a 20° angle of between a film cast on rough PVC and a film cast on smooth PVC of 10 gloss units.
• US7700833B2
  申请人：——

  公开号：US7700833B2

  公开（公告）日：2010-04-20
• US8945681B2
  申请人：——

  公开号：US8945681B2

  公开（公告）日：2015-02-03