N-(4-fluorobenzylidene)[2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]amine | 1052605-31-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(4-fluorobenzylidene)[2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]amine
• 英文别名: N-(4-fluorobenzylidene)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-amine；1-(4-fluorophenyl)-N-[2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]methanimine
• CAS: 1052605-31-8
• 化学式: C₂₀H₁₃F₂N₃
• 分子量: 333.34
• InChiKey: VWXKZKBAOKQPSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基吡啶 、 对氟苯甲醛 在 三甲基氰硅烷 、 溴化二甲基溴化锍 作用下， 反应 11.0h， 以70%的产率得到N-(4-fluorobenzylidene)[2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]amine
  参考文献：
  名称：

  (Bromodimethylsulfonium) bromide-catalyzed one-pot three-component synthesis of imidazo[1,2-a]pyridines

  摘要：

  Abstract(Bromodimethylsulfonium) bromide–catalyzed one‐pot multicomponent reaction of 2‐aminopyridine with aromatic aldehyde(s) and TMSCN yielding N‐benzylidene‐2‐phenylimidazo[1,2‐a]pyridines exclusively has been described. The reaction is solvent free, versatile, and takes significantly short time. J. Heterocyclic Chem., (2011).

  DOI：

  10.1002/jhet.518

文献信息

• BF₃/MCM-41 as nano structured solid acid catalyst for the synthesis of 3-iminoaryl-imidazo[1,2-a]pyridines
  作者：Mohammad Abdollahi-Alibeik、Ali Rezaeipoor-Anari

  DOI：10.1039/c3cy00947e

  日期：——

  of aldehydes, 2-aminopyridines and trimethylsilyl cyanide was carried out in the presence of MCM-41 supported boron trifluoride (BF3/MCM-41) as a nanostructured solid acid catalyst for the synthesis of 3-iminoaryl-imidazo[1,2-a]pyridine derivatives. MCM-41 nanoparticles were synthesized by a sol–gel method and BF3/MCM-41 samples with various loading amounts of BF3 and different calcination temperatures

  在MCM-41负载的三氟化硼（BF 3 / MCM-41）作为用于合成3-亚氨基芳基的纳米结构固体酸催化剂的存在下，进行了各种类型的醛，2-氨基吡啶和三甲基甲硅烷基氰化物的多组分反应。-咪唑并[1,2-a]吡啶衍生物。通过溶胶-凝胶法合成了MCM-41纳米粒子，并通过XRD，SEM和FT-IR技术制备了具有不同BF 3上样量和不同煅烧温度的BF 3 / MCM-41样品。催化性能实验表明，BF 3在400°C下煅烧的/ MCM-41具有最佳的催化活性。可回收性和可重复使用性实验表明，该催化剂可重复使用多次，且活性适度降低。
• A one-pot four-component synthesis of N-arylidene-2-aryl-imidazo[1,2-a]azin-3-amines
  作者：Abbas Rahmati、Ali Moazzam、Zahra Khalesi

  DOI：10.1016/j.tetlet.2014.03.098

  日期：2014.7

  N-Arylidene-2-aryl-imidazo[1,2-a]azin-3-amines were synthesized via a one-pot, four-component condensation reaction using a 2-aminoazine, toluene-4-sulfonylmethyl isocyanide (TsCH2NC), and two equivalents of readily available aromatic aldehydes. The reaction was performed in diethyl ether as the solvent, with p-toluenesulfonic acid (p-TSA) as the catalyst at reflux temperature. (C) 2014 Elsevier Ltd. All rights reserved.
• An efficient synthesis of 3-amino-2-arylimidazo[1,2-a]pyridines
  作者：Mehdi Adib、Esmail Sheibani、Long-Guan Zhu、Peiman Mirzaei

  DOI：10.1016/j.tetlet.2008.05.134

  日期：2008.8

  An efficient synthesis of 3-amino-2-arylimidazo[1,2-a]pyridines is described via a novel multicomponent reaction between 2-aminopyridines, benzaldehydes and imidazoline-2,4,5-trione under solvent-free conditions. (c) 2008 Elsevier Ltd. All rights reserved.