6-[2-Fluoro-6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide | 1941214-07-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-[2-Fluoro-6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide
• 英文别名: 6-[2-fluoro-6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]quinoline-3-carboxamide
• CAS: 1941214-07-8
• 化学式: C₂₃H₂₃FN₆O₂
• 分子量: 434.5
• InChiKey: BNPUWPZHENSNKH-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] COMBINATION OF ANTIBODY-DRUG CONJUGATE AND ATM INHIBITOR<br/>[FR] COMBINAISON D'UN CONJUGUÉ ANTICORPS-MÉDICAMENT ET D'UN INHIBITEUR DE L'ATM
  申请人：ASTRAZENECA UK LTD

  公开号：WO2021260580A1

  公开（公告）日：2021-12-30

  A pharmaceutical product for administration of an anti HER2 antibody-drug conjugate in combination with an ATM inhibitor is provided. The anti-HER2 antibody-drug conjugate is an antibody-drug conjugate in which a drug linker represented by the following formula (wherein A represents the connecting position to an antibody) is conjugated to an anti-HER2 antibody via a thioether bond. Also provided is a therapeutic use and method wherein the antibody-drug conjugate and the ATM inhibitor are administered in combination to a subject: Formula (I).