1-(7-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)quinolin-4-yl)-3-(pyrazin-2-yl)urea | 1192362-05-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(7-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)quinolin-4-yl)-3-(pyrazin-2-yl)urea
• 英文别名: 1-[7-(2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[2,3-c]pyrrol-5-yl)quinolin-4-yl]-3-pyrazin-2-ylurea
• CAS: 1192362-05-2
• 化学式: C₂₀H₂₁N₇O
• 分子量: 375.433
• InChiKey: JOHPGPONUWDFFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  95.1
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• 1-(7-(HEXAHYDROPYRROLO [3, 4-C] PYRROL-2 (1H)-YL) QUINOLIN-4-YL) -3- (PYRAZIN-2-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK-3)
  申请人：Turner Sean Colm

  公开号：US20110105528A1

  公开（公告）日：2011-05-05

  The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  本发明涉及一种新型杂环化合物，该化合物对于抑制糖原合酶激酶3（GSK-3）具有有用性，制备该化合物的方法，含有该化合物的组合物，以及使用该化合物的治疗方法。
• 1- (7-(HEXAHYDROPYRROLO [3, 4-C]PYRROL-2 (1H) -YL) QUIN0LIN-4-YL) -3- (PYRAZIN-2-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK-3) INHIBITORS
  申请人：Abbott GmbH & Co. KG

  公开号：EP2297154B1

  公开（公告）日：2013-04-03
• 1- (7-(HEXAHYDROPYRROLO [3, 4-C]PYRROL-2 (1H) -YL) QUIN0LIN-4-YL) -3- (PYRAZIN-2-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK-3)
  申请人：Abbott GmbH & Co. KG

  公开号：EP2297154A1

  公开（公告）日：2011-03-23
• US8455648B2
  申请人：——

  公开号：US8455648B2

  公开（公告）日：2013-06-04
• [EN] 1- (7-(HEXAHYDROPYRROLO [3, 4-C] PYRROL-2 (1H) -YL) QUIN0LIN-4-YL) -3- (PYRAZIN-2-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK-3)<br/>[FR] DÉRIVÉS DE 1-(7-(HEXAHYDROPYRROLO[3,4-C]PYRROL-2(1H)-YL)QUINOLÉIN-4-YL)-3-(PYRAZIN-2-YL)URÉE ET COMPOSÉS APPARENTÉS EN TANT QU'INHIBITEURS DE GLYCOGÈNE SYNTHASE KINASE 3 (GSK-3)
  申请人：ABBOTT GMBH & CO KG

  公开号：WO2009130317A1

  公开（公告）日：2009-10-29

  The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.