(2S)-N-(4-chlorophenyl)-2-[cis-4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide | 2227198-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (2S)-N-(4-chlorophenyl)-2-[cis-4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide
• 英文别名: (2S)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide
• CAS: 2227198-92-5
• 化学式: C₂₄H₂₄ClFN₂O
• 分子量: 410.9
• InChiKey: KRTIYQIPSAGSBP-GTPINHCMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US11236048B2

  公开（公告）日：2022-02-01

  The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

  本公开涉及改进的取代喹啉基环己基丙酰胺化合物的制备方法。
• RADIOLIGANDS FOR IMAGING THE IDO1 ENZYME
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20190282714A1

  公开（公告）日：2019-09-19

  The present invention relates to radiolabeled IDO1 inhibitors or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of IDO enzymes in mammals.
• SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20200123109A1

  公开（公告）日：2020-04-23

  The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.