2-cyano-N-pyridin-4-ylmethyl-3-[4-(2-pyridin-4-yl-trans-vinyl)phenyl]-E-acrylamide | 878795-78-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-cyano-N-pyridin-4-ylmethyl-3-[4-(2-pyridin-4-yl-trans-vinyl)phenyl]-E-acrylamide
• 英文别名: (E)-2-cyano-3-[4-[(E)-2-pyridin-4-ylethenyl]phenyl]-N-(pyridin-4-ylmethyl)prop-2-enamide
• CAS: 878795-78-9
• 化学式: C₂₃H₁₈N₄O
• 分子量: 366.422
• InChiKey: DPOGPFZPLQTVBG-QHFGVJFTSA-N

物化性质

• 沸点：
  678.5±55.0 °C(Predicted)
• 密度：
  1.251±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  78.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel compounds useful for modulating abnormal cell proliferation
  申请人：Roifman Chaim

  公开号：US20060058297A1

  公开（公告）日：2006-03-16

  There is described compounds of Formulae I, II, III, IV and V. The compounds of Formulae I, II, III, IV and/or V are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

  描述了公式I、II、III、IV和V的化合物。公式I、II、III、IV和/或V的化合物在调节细胞增殖的治疗方法和组合物中是有用的，在诊断检测中也是有用的，并可作为研究工具。
• EP1797064A4
  申请人：——

  公开号：EP1797064A4

  公开（公告）日：2009-06-24
• NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION
  申请人：THE HOSPITAL FOR SICK CHILDREN

  公开号：EP1797064A1

  公开（公告）日：2007-06-20
• US7807719B2
  申请人：——

  公开号：US7807719B2

  公开（公告）日：2010-10-05
• [EN] NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION<br/>[FR] NOUVEAUX COMPOSES UTILES A LA MODULATION DE LA PROLIFERATION CELLULAIRE ANORMALE
  申请人：HOSPITAL FOR SICK CHILDREN

  公开号：WO2006029515A1

  公开（公告）日：2006-03-23

  There is described compounds of Formula (I), (II), (III), (IV) and (V), the salts, solvates, and hydrates thereof and pharmaceutical compositions comprising these compounds. In Formula (II), A is a ring chosen from pyridine, pyrazine, pyrimidine, imidazole, furan and thiophene. In Formula (IV), A is a ring chosen from benzene, pyridine, pyrazine, pyrimidine, imidazole, furan and thiophene (either substituted or unsubstituted) and B is a ring chosen from benzene and pyridine. The compounds of Formula (I), (II), (III), (IV) and (V) are useful in therapeutic methods and compositions for modulating and inhibiting cell proliferation, such as cancer cell proliferation, in diagnostic assays and as research tools.