2-(5-Fluoro-pyridin-3-ylethynyl)-7,7-dimethyl-7,8-dihydro-6H-quinolin-5-one | 872123-26-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(5-Fluoro-pyridin-3-ylethynyl)-7,7-dimethyl-7,8-dihydro-6H-quinolin-5-one
• 英文别名: 2-[2-(5-Fluoropyridin-3-yl)ethynyl]-7,7-dimethyl-6,8-dihydroquinolin-5-one
• CAS: 872123-26-7
• 化学式: C₁₈H₁₅FN₂O
• 分子量: 294.328
• InChiKey: HOCSKZAWHBVORN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  42.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Tetrahydroquinolones and their use as modulators of metabotropic glutamate receptors
  申请人：Jirgensons Aigars

  公开号：US20050288284A1

  公开（公告）日：2005-12-29

  The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.

  该发明涉及乙炔基取代的四氢喹啉酮衍生物及其药学上可接受的盐。该发明进一步涉及一种制备这种化合物的方法。该发明的化合物是I组mGluR调节剂，因此对于控制和预防急性和/或慢性神经系统疾病有用。
• Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors
  申请人：Kauss Valerjans

  公开号：US20090227582A1

  公开（公告）日：2009-09-10

  The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.

  本发明涉及乙炔基取代的四氢喹啉酮衍生物以及其药学上可接受的盐。本发明还涉及一种制备这种化合物的方法。本发明的化合物是I组mGluR调节剂，因此对于控制和预防急性和/或慢性神经系统疾病是有用的。
• TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
  申请人：Merz Pharma GmbH & Co.KGaA

  公开号：EP1931635A1

  公开（公告）日：2008-06-18
• US7550482B2
  申请人：——

  公开号：US7550482B2

  公开（公告）日：2009-06-23
• [EN] TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS<br/>[FR] TÉTRAHYDROQUINOLINONES ET LEUR USAGE EN TANT QUE MODULATEURS DES RÉCEPTEURS DE GLUTAMATE MÉTABOTROPIQUES
  申请人：MERZ PHARMA GMBH & CO KGAA

  公开号：WO2007023242A1

  公开（公告）日：2007-03-01

  [EN] The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable a salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGIuR modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.
  [FR] L'invention concerne des dérivés de tétrahydroquinolinone à substitution éthynyle ainsi que leurs sels pharmaceutiquement acceptables. L'invention porte également sur un procédé permettant de préparer de tels composés. Les composés de cette invention sont des modulateurs de mGIuR de groupe I et sont par conséquent utiles lors du contrôle et de la prévention de troubles neurologiques aigus et/ou chroniques.