2-Cyan-3-phenyl-cis-hexen-(2)-saeure | 20374-64-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-Cyan-3-phenyl-cis-hexen-(2)-saeure
• 英文别名: (E)-2-cyano-3-phenylhex-2-enoic acid
• CAS: 20374-64-5
• 化学式: C₁₃H₁₃NO₂
• 分子量: 215.252
• InChiKey: NNNDXNMGIWZYHZ-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  61.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compounds
  申请人：Ford John

  公开号：US20050026935A1

  公开（公告）日：2005-02-03

  This invention relates to novel compound of formula (I) or pharmaceutically acceptable salts thereof. The invention is also directed to the uses of compounds having formula (I) in the treatment or prevention of diseases or disorders which requires potassium channel inhibition to an animal, mammal or human in need thereof. The invention is also directed to the use of compounds having formula (I) in the treatment or prevention of arrhythmia to an animal, mammal or human in need thereof.

  本发明涉及公式(I)的新化合物或其药学上可接受的盐。该发明还涉及使用具有公式(I)的化合物在需要钾通道抑制的动物、哺乳动物或人类中治疗或预防疾病或障碍的用途。该发明还涉及使用具有公式(I)的化合物在需要治疗或预防心律失常的动物、哺乳动物或人类中的用途。
• UV PROTECTION COMPOSITIONS
  申请人：The Procter & Gamble Company

  公开号：EP1121094A1

  公开（公告）日：2001-08-08
• THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS
  申请人：Xention Limited

  公开号：EP1641803B1

  公开（公告）日：2009-03-18
• US8022076B2
  申请人：——

  公开号：US8022076B2

  公开（公告）日：2011-09-20
• [EN] UV PROTECTION COMPOSITIONS<br/>[FR] COMPOSITIONS DE PROTECTION UV
  申请人：PROCTER & GAMBLE

  公开号：WO2000023044A1

  公开（公告）日：2000-04-27

  The present invention relates to compositions suitable for providing protection against the harmful effects of ultraviolet radiation. The compositions provide excellent efficiency, broad spectrum UV efficacy and photostability. Methods of use for these compositions are also disclosed. The present compositions comprise: a) an effective amount of a UVA-absorbing dibenzoylmethane sunscreen active; b) an effective amount of a styrene derivative, having formula (I), wherein at least one of R1, R2 and R3 is an electron-withdrawing substituent provided that R1 is other than an aryl and that R2 and R3 together do not form a camphor group; and R4 is selected from the group consisting of H, electron-donating substituents, and electron-withdrawing substituents other than an ether group or a cyano group; and c) a suitable carrier.