3-methoxymethyl-pentane-2,4-dione | 96609-12-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methoxymethyl-pentane-2,4-dione
• 英文别名: 3-Methoxymethyl-pentan-2,4-dion；3-Methoxymethyl-acetylaceton；3-(Methoxymethyl)pentane-2,4-dione
• CAS: 96609-12-0
• 化学式: C₇H₁₂O₃
• 分子量: 144.17
• InChiKey: IVPNQVGNEJJRRK-UHFFFAOYSA-N

物化性质

• 沸点：
  65 °C(Press: 4 Torr)
• 密度：
  0.993±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙酰丙酮化钠 、 氯甲基甲基醚 在 乙醚 作用下， 生成 3-methoxymethyl-pentane-2,4-dione
  参考文献：
  名称：

  Skin conditions in the pharmacy: consumer satisfaction and economic considerations

  摘要：

  评估维多利亚州社区药剂师提供的有关皮肤状况方面的建议是否令消费者满意，并估计在药房管理这些状况方面与消费者和政府相关的成本和潜在节省。

  1997-1998年，作为维多利亚州社区药剂师的州级教育计划的一部分，进行了有关成本和满意度的消费者调查。药剂师记录了涉及非处方药产品的皮肤病诊疗的详细情况，并招募药房消费者由研究团队成员进行后续跟进。

  在126家药房记录了消费者咨询。后来被采访的181位消费者中，105位（58.0％）报告称对他们的咨询非常满意。 132人（73.0％）花费不到10分钟咨询药剂师，78人（43.1％）花费了5至10澳元（1.95至2.60英镑）购买非处方药产品。共有37名消费者（20.4％）在药剂师的建议下咨询了医生。虽然这37名消费者中大多数在药房花费低于10澳元，但如果考虑医疗咨询的费用和医疗处方提供的物品的补贴性质，消费者和政府的成本将更高。药剂师在管理皮肤状况方面的直接成本低于一般医生的预期直接成本。

  消费者对药剂师在管理皮肤状况方面提供的建议和治疗感到满意。药剂师的建议对消费者和政府来说似乎也是经济划算的。社区药剂师似乎是提供轻微皮肤状况的建议和治疗的令人满意的初级提供者。

  DOI：

  10.1111/j.2042-7174.2001.tb01023.x

文献信息

• TUMOR SUPPRESSOR
  申请人：Wakabayashi Keiji

  公开号：US20090118314A1

  公开（公告）日：2009-05-07

  A compound having a sructure of propanedioic acid represented by the following formula ( 1 ): ( 1 ) (wherein the ring A represents oxazole or the like; R 1 represents an alkyl group, a lower alkoxy group or the like; R 2 and R 3 represent a lower alkyl group or the like; m represents 0 or an integer of 1 to 4, and m pieces of R 1 may be the same or different from each other; and W represents an integer of 3 to 5) is useful as an agent for preventing or treating a gastrointestinal polyp and/or a malignant tumor, or an agent for preventing metastasis thereof.

  具有丙二酸结构的化合物由下式(1)表示： (1)（其中环A代表噁唑或类似物；R1代表烷基、低级烷氧基或类似物；R2和R3代表低级烷基或类似物；m代表0或1至4的整数，m个R1可以相同也可以不同；W代表3至5的整数），可用作预防或治疗胃肠息肉和/或恶性肿瘤的药剂，或预防其转移的药剂。
• US4567004A
  申请人：——

  公开号：US4567004A

  公开（公告）日：1986-01-28
• US7442448B2
  申请人：——

  公开号：US7442448B2

  公开（公告）日：2008-10-28
• Skin conditions in the pharmacy: consumer satisfaction and economic considerations
  作者：Anne Plunkett、Phyllis Lau、Kay Stewart、Robin Marks

  DOI：10.1111/j.2042-7174.2001.tb01023.x

  日期：2011.2.22

  To evaluate whether consumers were satisfied with advice about skin conditions received from community pharmacists in Victoria, Australia, and to estimate costs and potential savings to the consumer and government associated with managing these conditions in the pharmacy.

  In 1997–1998, a consumer survey on costs and satisfaction was carried out in Victoria as part of a statewide education programme with community pharmacists. Pharmacists recorded details of dermatological consultations involving over-the-counter (OTC) products, and recruited pharmacy consumers for follow-up by a member of the research team.

  Consumer consultations were recorded at 126 pharmacies. One hundred and five (58.0 per cent) of the 181 consumers who were subsequently interviewed reported being very satisfied with their consultation. One hundred and thirty-two (73.0 per cent) spent up to 10 minutes consulting the pharmacist and 78 (43.1 per cent) spent between $A5 (£1.95) and $A10 on OTC products. A total of 37 consumers (20.4 per cent) consulted a medical practitioner on the advice of their pharmacist. While most of the 37 consumers spent under $A10 in the pharmacy, if the cost of medical consultation and the subsidised nature of items supplied on medical prescription were taken into account, the costs to the consumer and government would have been greater. The direct costs for a pharmacist consultation on the management of skin conditions were lower than the expected direct costs associated with a general practitioner (GP) consultation.

  Consumers were satisfied with the advice and treatment they received from the pharmacist on the management of skin conditions. Pharmacists' advice also appeared to be cost-effective for both the consumer and government. Community pharmacists appear to be satisfactory primary providers of advice and treatment for people with minor skin conditions.

  评估维多利亚州社区药剂师提供的有关皮肤状况方面的建议是否令消费者满意，并估计在药房管理这些状况方面与消费者和政府相关的成本和潜在节省。

  1997-1998年，作为维多利亚州社区药剂师的州级教育计划的一部分，进行了有关成本和满意度的消费者调查。药剂师记录了涉及非处方药产品的皮肤病诊疗的详细情况，并招募药房消费者由研究团队成员进行后续跟进。

  在126家药房记录了消费者咨询。后来被采访的181位消费者中，105位（58.0％）报告称对他们的咨询非常满意。 132人（73.0％）花费不到10分钟咨询药剂师，78人（43.1％）花费了5至10澳元（1.95至2.60英镑）购买非处方药产品。共有37名消费者（20.4％）在药剂师的建议下咨询了医生。虽然这37名消费者中大多数在药房花费低于10澳元，但如果考虑医疗咨询的费用和医疗处方提供的物品的补贴性质，消费者和政府的成本将更高。药剂师在管理皮肤状况方面的直接成本低于一般医生的预期直接成本。

  消费者对药剂师在管理皮肤状况方面提供的建议和治疗感到满意。药剂师的建议对消费者和政府来说似乎也是经济划算的。社区药剂师似乎是提供轻微皮肤状况的建议和治疗的令人满意的初级提供者。