(Z)-3-Isopentylidenephthalide | 56014-71-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: (Z)-3-Isopentylidenephthalide
• 英文别名: (Z)-3-isovalidenephthalide；(Z)-3-(3-Methylbutyliden)-phthalid；3-(3-Methylbutylidene)-1(3H)-isobenzofuranone；(3Z)-3-(3-methylbutylidene)-2-benzofuran-1-one
• CAS: 56014-71-2
• 化学式: C₁₃H₁₄O₂
• 分子量: 202.253
• InChiKey: LLCYNDRFWDIIQS-WQLSENKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  溴化异戊基三苯基磷 在 potassium tert-butylate 、 碘 、 sodium acetate 、 碳酸氢钠 、 potassium iodide 作用下， 以 乙醇 为溶剂， 反应 5.83h， 生成 (Z)-3-Isopentylidenephthalide
  参考文献：
  名称：

  Mali; Patil; Kulkarni, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1990, vol. 29, # 4, p. 319 - 321

  摘要：

  DOI：

文献信息

• Method for providing an increased expression of telomerase, brain-derived neurotrophic factor, stromal cell-derived factor-1, CXC chemokine receptor 4, and/or immune regulatory factor of stem cell
  申请人：HAWKING BIOLOGICAL TECHNOLOGY CO., LTD

  公开号：US11013716B2

  公开（公告）日：2021-05-25

  A method for providing an increased expression of at least one of telomerase, brain-derived neurotrophic factor (BDNF), stromal cell-derived factor-1 (SDF1), CXC chemokine receptor 4 (CXCR4), and an immune regulatory factor of a stem cell in a subject is provided. The method comprises simultaneously or separately administering to the subject an effective amount of (a) a phthalide and (b) a stem cell.

  本发明提供了一种增加受试者体内端粒酶、脑源性神经营养因子（BDNF）、基质细胞源性因子-1（SDF1）、CXC趋化因子受体4（CXCR4）和干细胞免疫调节因子中至少一种表达的方法。该方法包括同时或分别向受试者施用有效量的(a)邻苯二甲酸盐和(b)干细胞。
• Synthesis, resolution, and antiplatelet activity of 3-substituted 1(3H)-isobenzofuranone
  作者：Hua Yang、Gao-Yun Hu、Jun Chen、Yi Wang、Zhong-Hua Wang

  DOI：10.1016/j.bmcl.2007.06.082

  日期：2007.9

  A series of 3-substituted-1(3H)-isobenzofuranone 6a-g and 7a-g were synthesized from phthalic anhydride. The compound 6a-g was resolved. The antiplatelet activities of these compounds were evaluated using in vitro experiment of platelet aggregation. The levels of antiplatelet activity were displayed as following sequence: l-isomer > dl-isomer > d-isomer, respectively. The alkylphthalide is more active than the corresponding alkenephthalide. All these compounds were less active than n-butylphthalide (NBP, 6c) and Aspirin (Asp). (c) 2007 Elsevier Ltd. All rights reserved.
• Watanabe, Mitsuaki; Ijichi, Saori; Morimoto, Hitoshi, Heterocycles, 1993, vol. 36, # 3, p. 553 - 563
  作者：Watanabe, Mitsuaki、Ijichi, Saori、Morimoto, Hitoshi、Nogami, Kayoko、Furukawa, Sunao

  DOI：——

  日期：——
• MALI, R. S.;PATIL, S. R.;KULKARNI, B. K.;YEOLA, S. N., INDIAN J. CHEM. B , 29,(1990) N, C. 319-321
  作者：MALI, R. S.、PATIL, S. R.、KULKARNI, B. K.、YEOLA, S. N.

  DOI：——

  日期：——
• METHOD FOR INHIBITING AUTOPHAGY OF MOTOR NEURONS
  申请人：CHINA MEDICAL UNIVERSITY

  公开号：US20140045765A1

  公开（公告）日：2014-02-13

  A method for inhibiting the autophagy of motor neurons in a subject is provided. The method comprises administrating to the subject an effective amount of an active ingredient selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable ester of the compound and combinations thereof: wherein A is a C1-C5 alkyl optionally having one or more unsaturated bonds and optionally being substituted by one or more substituents selected from a group consisting of —OH, ═O and C1-C3 alkyl; X is H, —OH, Y is O or S and can optionally combine with A to form a five-membered ring; and R 1 is H or a substituted or unsubstituted C1-C20 alkyl, wherein one or more —CH 2 — of the C1-C20 alkyl are optionally being replaced by —NH— or —O—.