N²,N⁴-disalicyloyl-formohydrazidine | 98307-51-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N²,N⁴-disalicyloyl-formohydrazidine
• 英文别名: N²,N⁴-Disalicyloyl-formohydrazidin；<(2-Hydroxy-benzoyl)-hydrazono>-<(2-hydroxy-benzoyl)-hydrazino>-methan；N.N'-Bis(salicylyloylamino)formamidin；2-hydroxy-N-[[2-(2-hydroxybenzoyl)hydrazinyl]methylideneamino]benzamide
• CAS: 98307-51-8
• 化学式: C₁₅H₁₄N₄O₄
• 分子量: 314.301
• InChiKey: CUAHHICFHZBXRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.71
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  123.05
• 氢给体数：
  5.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  水杨酰肼 、 原甲酸三乙酯 以 乙醇 为溶剂， 反应 2.0h， 生成 N²,N⁴-disalicyloyl-formohydrazidine
  参考文献：
  名称：

  Vincent,M., Bulletin de la Societe Chimique de France, 1962, p. 1587 - 1591

  摘要：

  DOI：

文献信息

• Vincent,M., Bulletin de la Societe Chimique de France, 1962, p. 1587 - 1591
  作者：Vincent,M.

  DOI：——

  日期：——
• Inhibitory effect of metalloporphyrins in conjunction with cholesterol on hepatic phospholipase A2 activityin vivo in rats
  作者：Ramesh Chandra、Manisha Tiwari、Ritu Aneja、Sujata K. Dass、Archana Sharma

  DOI：10.1007/bf02883744

  日期：2000.7

  We investigated the effect of cholesterol and the metalloporphyrins cobalt mesoporphyrin (CoMP) and chromium protoporphyrin (CrPP) on phospholipase A(2) (PLA(2)) activity and the consequent hepatic mitochondrial stability as well as on lipid concentrations. Our studies revealed that on administration of cholesterol, CrPP, CoMP as well as simultaneous adminstration of cholesterol and CrPP, there was an inhibition of PLA(2) activity. These moieties may therefore, be agents for preventing destabilisation of the mitochondrial membrane and the consequent pathological conditions which may arise due to membrane lysis. Our results revealed that cholesterol administration increased phospholipid concentration, albeit by modest amounts. Although the independent administration of metalloporphyrins led only to minor elevations in phospholipid concentration, the simultaneous administration of cholesterol and CrPP generated a steep elevation in the concentration of total phospholipid. Since cholesterol inhibits PLA(2) activity it has the potential of being therapeutic agent for preventing the pathological conditions which may arise due to membrane lysis.