| 92427-20-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 92427-20-8
• 化学式: C₁₅H₁₀Cl₂O₂
• 分子量: 293.149
• InChiKey: OGXHKPASMOFVSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.32
• 重原子数：
  19.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  29.6
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  在 水 、 potassium hydrogencarbonate 、 Selectfluor 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以43%的产率得到1-(3,4-dichlorophenyl)-2-phenylethane-1,2-dione
  参考文献：
  名称：

  在无过渡金属条件下，Selectfluor介导的α，β-环氧酮中C-O和CC键的同时裂解：通往1,2-二酮的途径

  摘要：

  在无过渡金属条件下，Selectfluor介导的α，β-环氧酮中C-O和C-C键的同时裂解已成功实现。该反应以中等至良好的收率得到1,2-二酮化合物，包括在氧化条件下的开环/苯甲酰基重排/ CC键断裂序列。

  DOI：

  10.1021/acs.joc.5b00857

文献信息

• Solvent-Free Synthesis of 1,3-Diphenyl-5-arylpyrazole Derivatives
  作者：Ji-Tai Li、Ying Yin、Xian-Tao Meng

  DOI：10.2174/157017809788681383

  日期：2009.7.1

  The synthesis of 1,3-diphenyl-5-arylpyrazoles via the reactions of 2,3-epoxy-1-phenyl-3-aryl-1-propanones with phenylhydrazine was carried out in 48-84% yields at 230 °C under solvent-free condition within 1.5 h. This method provides several advantages such as operational simplicity, higher yield and solvent-free.

  该方法通过 2,3-环氧-1-苯基-3-芳基-1-丙酮与苯肼的反应合成 1,3-二苯基-5-芳基吡唑，在 230 °C 无溶剂条件下 1.5 小时内产率达到 48-84%。
• Ultrasound promoted efficient method for the cleavage of 3-aryl-2,3-epoxyl-1-phenyl-1-propanone with indole
  作者：Ji-Tai Li、Ming-Xuan Sun、Ying Yin

  DOI：10.1016/j.ultsonch.2009.09.004

  日期：2010.2

  An efficient synthesis of 3-aryl-3-hydroxy-2-(1H-inclol-3-yl)-1-phenyl-1-propanone via the cleavage of epoxides with indole promoted by ultrasound irradiation was carried out in good yields by using montmorillonite K10-ZnCl2 within 2-5 h at room temperature. This method provides several advantages such as operational simplicity, high yield and mild conditions. (C) 2009 Elsevier B.V. All rights reserved.
• A convenient and efficient protocol for the synthesis of 5-aryl-1,3-diphenylpyrazole catalyzed by hydrochloric acid under ultrasound irradiation
  作者：Ji-Tai Li、Ying Yin、Ling Li、Ming-Xuan Sun

  DOI：10.1016/j.ultsonch.2009.06.015

  日期：2010.1

  The synthesis of 5-aryl-1,3-diphenylpyrazole via the reactions of 3-aryl-2,3-epoxy-1-phenyl-1-propanone with phenylhydrazine was carried out in 69-99% yields at room temperature under ultrasound irradiation. This method provides several advantages such as operational simplicity, higher yield and environment friendly. (C) 2009 Elsevier B.V. All rights reserved.