1-[(6-fluoro-2-quinolyl)methyl]4-aminopiperidine | 431897-74-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-[(6-fluoro-2-quinolyl)methyl]4-aminopiperidine
• 英文别名: 1-[(6-Fluoroquinolin-2-yl)methyl]piperidin-4-amine
• CAS: 431897-74-4
• 化学式: C₁₅H₁₈FN₃
• 分子量: 259.326
• InChiKey: SRPIXKWCAUGFRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 4-(biphenylcarbonylamino)piperidine derivatives as mtp inhibitors
  申请人：——

  公开号：US20040034028A1

  公开（公告）日：2004-02-19

  The present invention relates to compounds of the formula (I): in which: Z represents biphenyl optionally substitute in position 2′, 3′, 4′, 5′ and 6′ with one or more substitutents chosen from trihalomethyl and trihalomethoxy; Het represents quinolyl, quinoxalyl or pyridyl optionally substituted with one or more substitutents chosen from halo, cyano, nitro, (C 1 -C 6 )alkyl, (C 6 -C 12 )aryl, (C 1 -C 6 )alkoxy, hydroxyl, (C 1 -C 6 )thioalkoxy, carboxyl and (C 1 -C 6 )alkoxycarbonyl, or pharmaceutically acceptable salts thereof. These compounds are useful as inhibitors of microsomal triglyceride transfer protein and as inhibitors of the secretion of B apoproteins.

  本发明涉及式(I)的化合物：其中：Z代表联苯，可选地在2′、3′、4′、5′和6′位上用三卤甲基和三卤甲氧基中的一种或多种取代基取代；Het代表喹啉基，喹啉并[1,4]二嗪基或吡啶基，可选地用卤素，氰基，硝基，(C1-C6)烷基，(C6-C12)芳基，(C1-C6)烷氧基，羟基，(C1-C6)硫代烷氧基，羧基和(C1-C6)烷氧羰基中的一种或多种取代基取代，或其药学上可接受的盐。这些化合物可用作微粒体甘油三酯转移蛋白的抑制剂，以及B类载脂蛋白分泌的抑制剂。
• 4-(BIPHENYLCARBONYLAMINO)PIPERIDINE DERIVATIVES AS MTP INHIBITORS
  申请人：MERCK PATENT GmbH

  公开号：EP1335912A1

  公开（公告）日：2003-08-20
• [EN] 4-(BIPHENYLCARBONYLAMINO)PIPERIDINE DERIVATIVES AS MTP INHIBITORS<br/>[FR] DERIVES DE 4-(BIPHENYLCARBONYLAMINO)PIPERIDINE UTILISES COMME INHIBITEURS DE L'MTP
  申请人：MERCK PATENT GMBH

  公开号：WO2002042291A1

  公开（公告）日：2002-05-30

  The present invention relates to compounds of the formula (I): in which: Z represents biphenyl optionally substitute in position 2', 3', 4', 5' and 6' with one or more substitutents chosen from trihalomethyl and trihalomethoxy; Het represents quinolyl, quinoxalyl or pyridyl optionally substituted with one or more substitutents chosen from halo, cyano, nitro, (C1-C6)alkyl, (C6-C12)aryl, (C1-C6)alkoxy, hydroxyl, (C1-C6)thioalkoxy, carboxyl and (C1-C6)alkoxycarbonyl, or pharmaceutically acceptable salts thereof. These compounds are useful as inhibitors of microsomal triglyceride transfer protein and as inhibitors of the secretion of B apoproteins.