3-(cyclopent-1-en-1-yl)-1H-pyrazole | 18714-88-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(cyclopent-1-en-1-yl)-1H-pyrazole
• 英文别名: 3-pyrazol；3-cyclopent-1-enyl-1(2)H-pyrazole；5-(cyclopenten-1-yl)-1H-pyrazole
• CAS: 18714-88-0
• 化学式: C₈H₁₀N₂
• 分子量: 134.181
• InChiKey: JGHMMIULJFZDBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.98
• 重原子数：
  10.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  28.68
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  5-chloro-7-morpholino-2-(pyridin-2-yl)furo[3,2-b]pyridine 、 3-(cyclopent-1-en-1-yl)-1H-pyrazole 在 tris-(dibenzylideneacetone)dipalladium(0) 、 caesium carbonate 、 ditert-butyl-[2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane-2-phenylethanamine chloropalladium⁽¹⁺⁾ 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 150.0 ℃ 、101.33 kPa 条件下， 以10 mg的产率得到5-(3-(cyclopent-1-en-1-yl)-1H-pyrazol-1-yl)-7-morpholino-2-(pyridin-2-yl)furo[3,2-b]pyridine
  参考文献：
  名称：

  [EN] 7-MORPHOLINO-5-(3-PHENYL-1 H-PYRAZOL-1 -YL)-FURO[3,2-B]PYRIDINE DERIVATIVES AND SIMILAR COMPOUNDS AS PIKFYVE KINASE INHIBITORS FOR THE TREATMENT OF E.G. AMYOTROPHIC LATERAL SCLEROSIS (ALS)
  [FR] DÉRIVÉS DE 7-MORPHOLINO-5-(3-PHÉNYL-1H-PYRAZOL-1-YL)-FURO[3,2-B]PYRIDINE ET COMPOSÉS SIMILAIRES SERVANT D'INHIBITEURS DE LA PIKFYVE KINASE POUR LE TRAITEMENT PAR EXEMPLE, DE LA SCLÉROSE LATÉRALE AMYOTROPHIQUE (ALS)

  摘要：

  The present invention relates to compounds of formula (I) that are inhibitors of PlKfyve kinase and are therefore useful for the treatment of e.g. neurological diseases, such as e.g. amyotrophic lateral sclerosis (ALS), Parkinson's disease, Alzheimer's disease, Huntington's disease, ADHD, schizophrenia, depression, or bipolar disorder. An exemplary compound is e.g. 7-morpholino-5-(3-phenyl-lH- pyrazol-l-yl)-2-(lH-pyrazol-4-yl)furo[3, 2-b]pyridine (compound 10) Data on the PlKfyve kinase inhibition are provided, e.g.:

  公开号：

  WO2022256299A1
• 作为产物：
  描述：

  3-(cyclopent-1-en-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 以45 mg的产率得到3-(cyclopent-1-en-1-yl)-1H-pyrazole
  参考文献：
  名称：

  [EN] 7-MORPHOLINO-5-(3-PHENYL-1 H-PYRAZOL-1 -YL)-FURO[3,2-B]PYRIDINE DERIVATIVES AND SIMILAR COMPOUNDS AS PIKFYVE KINASE INHIBITORS FOR THE TREATMENT OF E.G. AMYOTROPHIC LATERAL SCLEROSIS (ALS)
  [FR] DÉRIVÉS DE 7-MORPHOLINO-5-(3-PHÉNYL-1H-PYRAZOL-1-YL)-FURO[3,2-B]PYRIDINE ET COMPOSÉS SIMILAIRES SERVANT D'INHIBITEURS DE LA PIKFYVE KINASE POUR LE TRAITEMENT PAR EXEMPLE, DE LA SCLÉROSE LATÉRALE AMYOTROPHIQUE (ALS)

  摘要：

  The present invention relates to compounds of formula (I) that are inhibitors of PlKfyve kinase and are therefore useful for the treatment of e.g. neurological diseases, such as e.g. amyotrophic lateral sclerosis (ALS), Parkinson's disease, Alzheimer's disease, Huntington's disease, ADHD, schizophrenia, depression, or bipolar disorder. An exemplary compound is e.g. 7-morpholino-5-(3-phenyl-lH- pyrazol-l-yl)-2-(lH-pyrazol-4-yl)furo[3, 2-b]pyridine (compound 10) Data on the PlKfyve kinase inhibition are provided, e.g.:

  公开号：

  WO2022256299A1