2-(1-(3,4-dimethoxyphenyl)ethylidene)-N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)hydrazidecarbothioamide | 1119265-63-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(1-(3,4-dimethoxyphenyl)ethylidene)-N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)hydrazidecarbothioamide
• CAS: 1119265-63-2
• 化学式: C₂₅H₃₃N₃O₁₁S
• 分子量: 583.617
• InChiKey: QGHJIGPAQDCFHT-GNADVCDUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.98
• 重原子数：
  40.0
• 可旋转键数：
  10.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  169.31
• 氢给体数：
  2.0
• 氢受体数：
  13.0

反应信息

• 作为产物：
  描述：

  N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)thiosemicarbazide 、 3,4-二甲氧基苯乙酮 在 溶剂黄146 作用下， 以 异丙醇 为溶剂， 反应 5.0h， 以90%的产率得到2-(1-(3,4-dimethoxyphenyl)ethylidene)-N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)hydrazidecarbothioamide
  参考文献：
  名称：

  Syntheses and evaluation of glucosyl aryl thiosemicarbazide and glucosyl thiosemicarbazone derivatives as antioxidant and anti-dyslipidemic agents

  摘要：

  A series of N-per-O-acetyl-glucosyl arylthiosemicarbazide and thiosemicarbazone derivatives have been synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Among 16 compounds tested, 3 compounds showed potent anti-dyslipidemic activity and 6 compounds showed potent antioxidant and scavenger of oxygen free radicals activity. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.070