1-(3-溴-丙-2-炔基)-环己醇 | 90674-85-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(3-溴-丙-2-炔基)-环己醇
• 英文名称: 1-(3-bromo-prop-2-ynyl)-cyclohexanol
• 英文别名: 1-(3-Brom-prop-2-inyl)-cyclohexanol；1-(3-Bromo-2-propyn-1-yl)cyclohexanol；1-(3-bromoprop-2-ynyl)cyclohexan-1-ol
• CAS: 90674-85-4
• 化学式: C₉H₁₃BrO
• 分子量: 217.106
• InChiKey: GXDDNECFHNANBQ-UHFFFAOYSA-N

物化性质

• 熔点：
  31-33 °C
• 沸点：
  65 °C(Press: 0.5 Torr)
• 密度：
  1.424±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.43
• 重原子数：
  11.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  1-(3-溴-丙-2-炔基)-环己醇 在 gold(III) chloride 、 水 作用下， 以 甲苯 为溶剂， 反应 15.0h， 以90%的产率得到1-羟基环己烷丙酸 gamma-内酯
  参考文献：
  名称：

  A New Synthesis of γ-Butyrolactones via AuCl₃- or Hg(II)-Catalyzed Intramolecular Hydroalkoxylation of 4-Bromo-3-yn-1-ols

  摘要：

  An efficient conversion of 4-bromo-3-yn-1-ols to gamma-butyrolactones via AuCl3-catalyzed electrophilic cyclization (hydroxyl-assisted regioselective hydration) in wet toluene is described. Various secondary and tertiary alcohols including benzylic systems were found to be equally reactive with moderate to excellent yields obtained in all cases.

  DOI：

  10.1021/ol2033493
• 作为产物：
  描述：

  1-(2-丙炔基)环己烷-1-醇 生成 1-(3-溴-丙-2-炔基)-环己醇
  参考文献：
  名称：

  取代的炔丙基甲醇及其催眠作用†

  摘要：

  通过使炔丙基溴与酮缩合制备了三十种叔炔丙基甲醇。其中一些表现出比3-甲基戊炔-3-01更好的催眠活性。该系列中最好的化合物是1-氯-2-氯甲基戊-4-yn-2-01，事实证明它是一种非常有效的催眠药，具有良好的治疗指数。

  DOI：

  10.1002/hlca.19590420312

文献信息

• The Prevalence of Daytime Napping and Its Relationship to Nighttime Sleep
  作者：June J. Pilcher、Kristin R. Michalowski、Renee D. Carrigan

  DOI：10.1080/08964280109595773

  日期：2001.1

  Many healthy adults report daytime napping. Surprisingly few studies, however have examined spontaneous napping behavior especially very short naps, in healthy adults. The authors examined the prevalence of power naps (lasting less than 20 minutes) and longer naps (20 minutes or more) and their effects on nighttime sleep in a group of healthy young and middle-aged adults. The young and middle-aged adults reported very similar sleep and napping patterns, with approximately 74% of the participants in both groups reporting they had napped during a 7-day sleep-log period. Almost half of the participants reported that the average nap lasted less than 20 minutes. A multivariant analysis of variance (MANOVA) found no significant differences between the no-nap and the power-nap or long-nap groups in sleep quantity or quality for either age group. The current data suggested that power napping occurs frequently in healthy adults and that spontaneous napping does not negatively affect nighttime sleep.