| 1414356-85-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1414356-85-6
• 化学式: C₁₄H₂₁NO₂
• 分子量: 235.326
• InChiKey: RIGHAQFLCURSQB-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 三氟乙酸铵 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 以66%的产率得到2-(2,2-dimethylpropyl)-6,6-dimethyl-5,7-dihydro-1H-benzimidazol-4-one
  参考文献：
  名称：

  Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates

  摘要：

  A set of low molecular weight compounds containing a hydroxyethylamine (HEA) core structure with different prime side alkyl substituted 4,5,6,7-tetrahydrobenzazoles and one 4,5,6,7-tetrahydropyridinoazole was synthesized. Striking differences were observed on potencies in the BACE-1 enzymatic and cellular assays depending on the nature of the heteroatoms in the bicyclic ring, from the low active compound 4 to inhibitor 6, displaying BACE-1 IC50 values of 44 nM (enzyme assay) and 65 nM (cell-based assay). (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.08.097