7-O-(heptaacetyl-β-D-cellobiosyl)-40-O-(tetraacetyl-β-D-glycosyl)apigenin | 1381874-75-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 7-O-(heptaacetyl-β-D-cellobiosyl)-40-O-(tetraacetyl-β-D-glycosyl)apigenin
• CAS: 1381874-75-4
• 化学式: C₅₅H₆₂O₃₁
• 分子量: 1219.08
• InChiKey: OMUXQIPAGVRSPO-NKXJZJHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.63
• 重原子数：
  86.0
• 可旋转键数：
  21.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  395.12
• 氢给体数：
  1.0
• 氢受体数：
  31.0

反应信息

• 作为反应物：
  描述：

  7-O-(heptaacetyl-β-D-cellobiosyl)-40-O-(tetraacetyl-β-D-glycosyl)apigenin 在 甲醇 、 potassium methanolate 作用下， 以 氯仿 为溶剂， 反应 2.0h， 以94%的产率得到7-O-β-D-cellobiosyl-4'-O-β-D-glycosylapigenin
  参考文献：
  名称：

  The first total synthesis of apigenin 7-O-β-D-cellobiosyl-4′-O-β-D-glucopyranoside isolated from Salvia uliginosa

  摘要：

  The first total synthesis of apigenin 7-O--D-cellobioside (5) and apigenin 7-O--D-cellobiosyl-4-O--D-glucopyranoside (8), which were isolated from petals of Salvia patens and Salvia uliginosa, were achieved in four and six steps and 76% and 57%, respectively, overall yield, from naringenin (1). The total synthesis contained two-glycosylation, acetylation, oxidation, selective deacetylation and deprotection steps. Although this route contained six steps, the targeted compounds were obtained with higher yields and easier purifications than other synthetic methods.

  DOI：

  10.1080/14786419.2012.686908
• 作为产物：
  描述：

  (S)-柚皮素 在 喹啉 、 甲醇 、 silver carbonate 、 N-溴代丁二酰亚胺(NBS) 、 硫酸 、 ammonium acetate 、 过氧化苯甲酰 作用下， 以 四氢呋喃 、 四氯化碳 、 水 为溶剂， 反应 35.25h， 生成 7-O-(heptaacetyl-β-D-cellobiosyl)-40-O-(tetraacetyl-β-D-glycosyl)apigenin
  参考文献：
  名称：

  The first total synthesis of apigenin 7-O-β-D-cellobiosyl-4′-O-β-D-glucopyranoside isolated from Salvia uliginosa

  摘要：

  The first total synthesis of apigenin 7-O--D-cellobioside (5) and apigenin 7-O--D-cellobiosyl-4-O--D-glucopyranoside (8), which were isolated from petals of Salvia patens and Salvia uliginosa, were achieved in four and six steps and 76% and 57%, respectively, overall yield, from naringenin (1). The total synthesis contained two-glycosylation, acetylation, oxidation, selective deacetylation and deprotection steps. Although this route contained six steps, the targeted compounds were obtained with higher yields and easier purifications than other synthetic methods.

  DOI：

  10.1080/14786419.2012.686908