3-methyl-2-phenylamino-5-[5-(2,5,7,10-tetraoxa-14-aza-tricyclo[9.8.0.013,18]nonadeca-1(11),12,14,16,18-pentaen-17-yloxy)-pyridin-2-yl]-3H-pyrimidin-4-one | 1355620-71-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-methyl-2-phenylamino-5-[5-(2,5,7,10-tetraoxa-14-aza-tricyclo[9.8.0.013,18]nonadeca-1(11),12,14,16,18-pentaen-17-yloxy)-pyridin-2-yl]-3H-pyrimidin-4-one
• 英文别名: 3-methyl-2-phenylamino-5-[5-(2,5,7,10-tetraoxa-14-azatricyclo[ 9.8.0.013,18]-nonadecane-1(11),12,14,16,18-pentaen-17-yloxy)pyridin-2-yl]-3H-pyrimidin-4-one；2-Anilino-3-methyl-5-[5-(2,5,7,10-tetraoxa-14-azatricyclo[9.8.0.013,18]nonadeca-1(19),11,13,15,17-pentaen-17-yloxy)pyridin-2-yl]pyrimidin-4-one
• CAS: 1355620-71-1
• 化学式: C₃₀H₂₇N₅O₆
• 分子量: 553.574
• InChiKey: DNHDQZLOUAQTJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  41
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  117
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Novel Fused Heterocyclic Derivatives Useful as c-Met Tyrosine Kinase Inhibitors
  申请人：Hu Shaojing

  公开号：US20130123286A1

  公开（公告）日：2013-05-16

  Certain novel fused quinazoline derivatives of formula (I) as c-Met inhibitors, their synthesis and their uses for treating a c-Met mediated disorder. Methods for treating a c-Met-mediated disorder are also disclosed in the invention.

  某些新型融合喹唑啉衍生物（化学式（I））作为c-Met抑制剂，它们的合成以及用于治疗c-Met介导的疾病的用途。该发明还公开了治疗c-Met介导的疾病的方法。
• NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS C-MET TYROSINE KINASE INHIBITORS
  申请人：Betta Pharmaceuticals Co., Ltd.

  公开号：EP2593462B1

  公开（公告）日：2016-09-07
• US9242991B2
  申请人：——

  公开号：US9242991B2

  公开（公告）日：2016-01-26