4-bromo-2-(1H-pyrazol-5-yl)aniline | 145369-95-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-bromo-2-(1H-pyrazol-5-yl)aniline
• CAS: 145369-95-5
• 化学式: C₉H₈BrN₃
• 分子量: 238.087
• InChiKey: LLPDNSCAEOUMDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-bromo-2-(1H-pyrazol-5-yl)aniline 、 对甲苯磺酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以88%的产率得到N-(4-bromo-2-{1-[(4-methylphenyl)sulfonyl]-1H-pyrazol-3-yl}phenyl)-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Synthesis andin vitroEvaluation of New Benzenesulfonamides as Antileishmanial Agents

  摘要：

  This paper describes the synthesis and the antileishmanial activity of new pyrazolyl benzenesulfonamide derivatives. These were elucidated by spectrometric methods. Some compounds showed a significant in vitro activity against Leishmania amazonensis, highlighting the derivative 1e. These pyrazolyl benzenesulfonamide derivatives did not show any toxicity in murine macrophage.

  DOI：

  10.5935/0103-5053.20140062
• 作为产物：
  描述：

  6-溴-4-氯喹啉 在 肼 作用下， 以 二乙二醇 为溶剂， 反应 7.0h， 生成 4-bromo-2-(1H-pyrazol-5-yl)aniline
  参考文献：
  名称：

  Synthesis andin vitroEvaluation of New Benzenesulfonamides as Antileishmanial Agents

  摘要：

  This paper describes the synthesis and the antileishmanial activity of new pyrazolyl benzenesulfonamide derivatives. These were elucidated by spectrometric methods. Some compounds showed a significant in vitro activity against Leishmania amazonensis, highlighting the derivative 1e. These pyrazolyl benzenesulfonamide derivatives did not show any toxicity in murine macrophage.

  DOI：

  10.5935/0103-5053.20140062

文献信息

• Improvements in or relating to excitatory amino acid receptor antagonists
  申请人：ELI LILLY AND COMPANY

  公开号：EP0518530B1

  公开（公告）日：1996-10-09
• US5196421A
  申请人：——

  公开号：US5196421A

  公开（公告）日：1993-03-23
• US5153196A
  申请人：——

  公开号：US5153196A

  公开（公告）日：1992-10-06
• Synthesis and<i>in vitro</i>Evaluation of New Benzenesulfonamides as Antileishmanial Agents
  作者：Julio C. Borges、Adriana V. Carvalho、Alice M. R. Bernardino、César D. Oliveira、Luiz C. S. Pinheiro、Roberta K. F. Marra、Helena C. Castro、Solange M. S. V. Wardell、James L. Wardell、Veronica F. Amaral、Marilene M. Canto-Cavalheiro、Leonor L. Leon、Marcelo Genestra

  DOI：10.5935/0103-5053.20140062

  日期：——

  This paper describes the synthesis and the antileishmanial activity of new pyrazolyl benzenesulfonamide derivatives. These were elucidated by spectrometric methods. Some compounds showed a significant in vitro activity against Leishmania amazonensis, highlighting the derivative 1e. These pyrazolyl benzenesulfonamide derivatives did not show any toxicity in murine macrophage.