4-nitrophenyl α-L-idoseptanoside | 882029-49-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-nitrophenyl α-L-idoseptanoside
• 英文别名: (2S,3R,4S,5R,6S)-2-(4-nitrophenoxy)oxepane-3,4,5,6-tetrol
• CAS: 882029-49-4
• 化学式: C₁₂H₁₅NO₈
• 分子量: 301.253
• InChiKey: XARNRAYXLOBZKX-MJDLHHQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  145
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-nitrophenyl 2,3,4,5-tetra-O-benzoyl-α-L-idoseptanoside 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以60%的产率得到4-nitrophenyl α-L-idoseptanoside
  参考文献：
  名称：

  l-Idoseptanosides: substrates of d-glucosidases?

  摘要：

  Based on the reported glycosidase inhibitory activities of 1,6-dideoxy-1,6-imino-L-iditol, the corresponding aryl glycosides 4-nitrophenyl alpha- and beta-L -idoseptano side 7 and 8 were synthesised as possible glycosidase substrates. Despite their inherently larger size, these septanosides were indeed shown to be glycosidase substrates, albeit weak ones. In addition, these two substrate analogues 7 and 8 also demonstrated a remarkable degree of selectivity for beta- and alpha-glucosidases, respectively. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.12.007