(2E)-1-(2',4',5'-trimethoxyphenyl)-3-(2-chloro-6-methoxyquinolin-3-yl)-2-propen-1-one | 1355970-37-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (2E)-1-(2',4',5'-trimethoxyphenyl)-3-(2-chloro-6-methoxyquinolin-3-yl)-2-propen-1-one
• CAS: 1355970-37-4
• 化学式: C₂₂H₂₀ClNO₅
• 分子量: 413.858
• InChiKey: PXQOWLAMPOGELQ-VMPITWQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.82
• 重原子数：
  29.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  66.88
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  2-氯-6-甲氧基喹啉-3-甲醛 、 2′,4′,5′-三甲氧基苯乙酮 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以86%的产率得到(2E)-1-(2',4',5'-trimethoxyphenyl)-3-(2-chloro-6-methoxyquinolin-3-yl)-2-propen-1-one
  参考文献：
  名称：

  Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus

  摘要：

  The increase in antibiotic resistance due to multiple factors has encouraged the search for new compounds which are active against multidrug-resistant pathogens. In this context, chalcones, dihydrochalcones, hydrazones and oxadiazoles were tested against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus (MRSA) isolates, which were obtained from clinical laboratories and were characterized as MRSA using traditional and molecular methods. Among 65 tested compounds, two chalcones, one dihydrochalcone and two hydrazones were active against MRSA. Based on the minimal inhibitory concentration and cytotoxicity, hydrazones provided a better selectivity index than chalcones. Active hydrazones are promising antibiotic-like substances and they should be the subject of further microbiological studies. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.11.059