(4-chloro-phenyl)-(1,3-diphenylallyl)amine | 1062573-86-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (4-chloro-phenyl)-(1,3-diphenylallyl)amine
• 英文别名: 4-chloro-N-[(E,1R)-1,3-diphenylprop-2-enyl]aniline
• CAS: 1062573-86-7
• 化学式: C₂₁H₁₈ClN
• 分子量: 319.834
• InChiKey: DTVLVJFMNOVKHS-RBNQXFGJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  对氯苯胺 、 ethyl (E)-1,3-diphenyl-2-propen-1-yl carbonate 在 bis(η3-allyl-μ-chloropalladium(II)) 三乙烯二胺 、 N,O-双三甲硅基乙酰胺 作用下， 以 乙醚 为溶剂， 反应 22.17h， 以99%的产率得到(4-chloro-phenyl)-(1,3-diphenylallyl)amine
  参考文献：
  名称：

  Pd-catalyzed asymmetric allylic aminations with aromatic amine nucleophiles using chiral diaminophosphine oxides: DIAPHOXs

  摘要：

  Asymmetric allylic aminations with aromatic amine nucleophiles using Pd-DIAPHOX catalyst systems are described. The asymmetric allylic aminations of various allylic carbonates proceeded using 2-5 mol % of the catalyst and BSA, providing the corresponding N-aryl chiral allylic amines in up to 99% ee for cyclic substrates, and in up to 97% ee for acyclic substrates. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.07.015

文献信息

• Pd-catalyzed asymmetric allylic aminations with aromatic amine nucleophiles using chiral diaminophosphine oxides: DIAPHOXs
  作者：Tetsuhiro Nemoto、Shinji Tamura、Tatsurou Sakamoto、Yasumasa Hamada

  DOI：10.1016/j.tetasy.2008.07.015

  日期：2008.7

  Asymmetric allylic aminations with aromatic amine nucleophiles using Pd-DIAPHOX catalyst systems are described. The asymmetric allylic aminations of various allylic carbonates proceeded using 2-5 mol % of the catalyst and BSA, providing the corresponding N-aryl chiral allylic amines in up to 99% ee for cyclic substrates, and in up to 97% ee for acyclic substrates. (C) 2008 Elsevier Ltd. All rights reserved.