[2R,4S]4-amino-2-methyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester | 261947-61-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [2R,4S]4-amino-2-methyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester
• 英文别名: ethyl (2R,4S)-4-amino-2-methyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
• CAS: 261947-61-9
• 化学式: C₁₄H₁₇F₃N₂O₂
• 分子量: 302.296
• InChiKey: UUOXLDMJXBDZGI-KCJUWKMLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 4-AMINO SUBSTITUTED-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS
  申请人：Pfizer Products Inc.

  公开号：EP1114032A1

  公开（公告）日：2001-07-11
• US6140343A
  申请人：——

  公开号：US6140343A

  公开（公告）日：2000-10-31
• US6489478B1
  申请人：——

  公开号：US6489478B1

  公开（公告）日：2002-12-03
• [EN] 4-AMINO SUBSTITUTED-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS<br/>[FR] 4-AMINO SUBSTITUE-2-SUBSTITUE-1,2,3,4-TETRAHYDROQUINOLINES UTILISEES COMME INHIBITEURS DE CETP
  申请人：PFIZER PROD INC

  公开号：WO2000017165A1

  公开（公告）日：2000-03-30

  Cholesteryl ester transfer protein inhibitors, of the Formula (I), prodrug thereof, or a pharmaceutically acceptable salt of said compound or of said prodrug, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.