3'-methylspiro[cyclopropane-1,6'-pyrrolo[1,2-c]imidazole-5',7'-dione] | 1218792-89-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3'-methylspiro[cyclopropane-1,6'-pyrrolo[1,2-c]imidazole-5',7'-dione]
• 英文别名: 3'-Methylspiro[cyclopropane-1,6'-pyrrolo[1,2-c]imidazole]-5',7'-dione；3'-methylspiro[cyclopropane-1,6'-pyrrolo[1,2-c]imidazole]-5',7'-dione
• CAS: 1218792-89-2
• 化学式: C₉H₈N₂O₂
• 分子量: 176.175
• InChiKey: AJWSMVCXKVBHJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  52
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲基咪唑 、 1,1-环丙烷二羰基二氯化物 在 三乙胺 作用下， 以 乙腈 为溶剂， 以71%的产率得到3'-methylspiro[cyclopropane-1,6'-pyrrolo[1,2-c]imidazole-5',7'-dione]
  参考文献：
  名称：

  Reactions of 2-alkylimidazoles and 2-methylbenzimidazoles with 1,3-diacid chlorides. Synthesis of highly functionalized hetero-cycles under mild conditions

  摘要：

  Highly functionalized heterocycles were synthesized in one-pot reactions of 2-alkylimidazoles or 2-methylbenzimidazoles with 1,3-diacid chlorides. Some of the cyclizations proceed through cyclic-N,N'-ketene acetal intermediates. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.10.116

文献信息

• Reactions of 2-alkylimidazoles and 2-methylbenzimidazoles with 1,3-diacid chlorides. Synthesis of highly functionalized hetero-cycles under mild conditions
  作者：Sabornie Chatterjee、Guozhong Ye、Charles U. Pittman

  DOI：10.1016/j.tetlet.2009.10.116

  日期：2010.2

  Highly functionalized heterocycles were synthesized in one-pot reactions of 2-alkylimidazoles or 2-methylbenzimidazoles with 1,3-diacid chlorides. Some of the cyclizations proceed through cyclic-N,N'-ketene acetal intermediates. (C) 2009 Elsevier Ltd. All rights reserved.