5-methoxymethyl-1,2-dihydro-[1,2,4]triazole-3-thione | 78201-12-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-methoxymethyl-1,2-dihydro-[1,2,4]triazole-3-thione
• 英文别名: 5-Methoxymethyl-1,2-dihydro-[1,2,4]triazol-3-thion；3-(methoxymethyl)-1H-1,2,4-triazole-5-thiol；5-(methoxymethyl)-1,2-dihydro-1,2,4-triazole-3-thione
• CAS: 78201-12-4
• 化学式: C₄H₇N₃OS
• mdl: MFCD14611323
• 分子量: 145.185
• InChiKey: YIMAHMOQUGYTKN-UHFFFAOYSA-N

物化性质

• 熔点：
  185-187 °C
• 沸点：
  181.1±42.0 °C(Predicted)
• 密度：
  1.50±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  77.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-methoxymethyl-1,2-dihydro-[1,2,4]triazole-3-thione 在 硝酸 作用下， 生成 3-(methoxymethyl)-1H-1,2,4-triazole
  参考文献：
  名称：

  1,2,4-Triazole-3-alanine

  摘要：

  DOI：

  10.1021/ja01611a040
• 作为产物：
  描述：

  甲氧基乙酰氯 、 sodium methylate 在 吡啶 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 48.0h， 以33%的产率得到5-methoxymethyl-1,2-dihydro-[1,2,4]triazole-3-thione
  参考文献：
  名称：

  NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES

  摘要：

  公开号：

  EP1598349B1

文献信息

• Substituted Quinazoline or Pyridopyrimidine Derivative
  申请人：Mitsuya Morihiro

  公开号：US20080032996A1

  公开（公告）日：2008-02-07

  The present invention provides a compound having a glucokinase activating action being useful for prevention or treatment of diabetes mellitus, etc. being represented by the formula (I): X is nitrogen atom, etc.; Y is oxygen atom, etc.; R 1 is an optionally substituted five to six-membered heteroaryl group, etc.; R 2 is hydrogen atom or fluorine atom; and ring A is a monocyclic or bicyclic heteroaryl group which may have a substituent represented by the formula (II)] or a pharmaceutically acceptable salt thereof.

  本发明提供了一种具有激活葡萄糖激酶作用的化合物，该化合物可用于预防或治疗糖尿病等疾病，其表示式为(I)：其中，X为氮原子等；Y为氧原子等；R1为可选取代的五至六元杂环芳基基团等；R2为氢原子或氟原子；环A为单环或双环杂环芳基基团，其可具有由式(II)表示的取代基，或其药学上可接受的盐。
• Novel 2-pyridinecarboxamide derivatives
  申请人：Mitsuya Morihiro

  公开号：US20060258701A1

  公开（公告）日：2006-11-16

  The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X 1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R 1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R and R 3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.

  本发明涉及一种化合物，具有激活葡萄糖激酶的效果，并可用作糖尿病治疗剂，其化学式表示为（I）：[其中X1表示氮原子、硫原子、氧原子或类似物；R1表示6-至10-成员芳基基团、5-至7-成员杂芳基基团或类似物；D表示氧原子或硫原子；R和R3相同或不同，分别表示氢原子、低碳基或类似物；式（II）表示可选取代的5-至7-成员杂芳基团或类似物；式（III）表示单环或双环杂芳基团]或其药学上可接受的盐。
• 2-pyridinecarboxamide derivatives
  申请人：MSD K. K.

  公开号：US08344003B2

  公开（公告）日：2013-01-01

  The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.

  本发明涉及一种具有葡萄糖激酶激活作用的化合物，可用作糖尿病治疗剂，其化学式表示为（I）：[其中X1表示氮原子、硫原子、氧原子或类似物；R1表示6-至10-成员芳基基团、5-至7-成员杂芳基团或类似物；D表示氧原子或硫原子；R2和R3相同或不同，分别表示氢原子、较低的烷基基团或类似物；式（II）表示可选地取代的5-至7-成员杂芳基团或类似物；式（III）表示单环或双环杂芳基团]或其药学上可接受的盐。
• 2-pyridine carboxamide derivatives
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US07629362B2

  公开（公告）日：2009-12-08

  The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.

  本发明涉及一种具有葡萄糖激酶激活作用的化合物，可用作糖尿病治疗剂，其化学式为（I）：[其中X1表示氮原子、硫原子、氧原子或类似物；R1表示6-至10-成员的芳基基团、5-至7-成员的杂环芳基基团或类似物；D表示氧原子或硫原子；R2和R3相同或不同，分别表示氢原子、低碳基基团或类似物；化学式（II）表示可选取代的5-至7-成员的杂环芳基基团或类似物；化学式（III）表示单环或双环杂环芳基基团] 或其药学上可接受的盐。
• Substituted quinazoline or pyridopyrimidine derivative
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US07687502B2

  公开（公告）日：2010-03-30

  The present invention provides a compound having a glucokinase activating action being useful for prevention or treatment of diabetes mellitus, etc. being represented by the formula (I): X is nitrogen atom, etc.; Y is oxygen atom, etc.; R1 is an optionally substituted five to six-membered heteroaryl group, etc.; R2 is hydrogen atom or fluorine atom; and ring A is a monocyclic or bicyclic heteroaryl group which may have a substituent represented by the formula (II)] or a pharmaceutically acceptable salt thereof.

  本发明提供了一种具有激活葡萄糖激酶作用的化合物，其表示为式（I）：X为氮原子等；Y为氧原子等；R1为可选取代的五到六元杂环芳基等；R2为氢原子或氟原子；环A为单环或双环杂环芳基，其可以具有由式（II）表示的取代基，或其药学上可接受的盐，用于预防或治疗糖尿病等。