1-furan-2-yl-3-pyridin-3-ylpropenone | 127143-99-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-furan-2-yl-3-pyridin-3-ylpropenone
• 英文别名: 1-(Furan-2-yl)-3-pyridin-3-ylprop-2-en-1-one
• CAS: 127143-99-1
• 化学式: C₁₂H₉NO₂
• 分子量: 199.209
• InChiKey: LVVLNTUVIGKOGB-UHFFFAOYSA-N

物化性质

• 熔点：
  106-108 °C(Solv: benzene (71-43-2))
• 沸点：
  341.6±42.0 °C(Predicted)
• 密度：
  1.201±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-氰基硫代乙酰胺 、 1-furan-2-yl-3-pyridin-3-ylpropenone 在 sodium methylate 作用下， 以65%的产率得到6-(furan-2-yl)-4-pyridin-3-yl-2-sulfanylidene-1H-pyridine-3-carbonitrile
  参考文献：
  名称：

  Vieweg, H.; Hanfeld, Vera; Leistner, S., Pharmazie, 1989, vol. 44, # 9, p. 639 - 640

  摘要：

  DOI：
• 作为产物：
  描述：

  3-吡啶甲醛 、 2-乙酰基呋喃 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 12.0h， 以47%的产率得到1-furan-2-yl-3-pyridin-3-ylpropenone
  参考文献：
  名称：

  Vieweg, H.; Hanfeld, Vera; Leistner, S., Pharmazie, 1989, vol. 44, # 9, p. 639 - 640

  摘要：

  DOI：

文献信息

• [EN] NOVEL PROPENONE DERIVATIVES CONTAINING AROMATIC RINGS, A MAUFACTURING PROCESS THEREOF AND A COMPOSITION CONTAINING THE SAME USING AS AN ANTIINFLAMMATORY AGENT<br/>[FR] NOUVEAUX DERIVES DE PROPENONE CONTENANT UN CYCLE AROMATIQUE, LEUR PROCEDE DE PRODUCTION, ET COMPOSITION LES CONTENANT EN TANT QU'AGENTS ANTI-INFLAMMATOIRES
  申请人：YEUNGNAM EDUCATIONAL FOUND

  公开号：WO2005121129A1

  公开（公告）日：2005-12-22

  The present invention is related to novel propenone derivatives containing aromatic ring, a manufacturing process thereof and a composition containing the same using as an anti¬ inflammatory agent. The compound of the present invention show potent anti-inflammatory activity confirmed by various experiments for example, the inhibition test of COX and 5-LOX enzyme activity, the inhibition test of LTC reproduction and NO production, MTT assay test, the inhibition test on the iNOS and COX-2 protein expression and PGE reproduction using RAW 264.7 macrophage etc. Accordingly, present compounds can be useful in treating and preventing various inflammatory.

  本发明涉及含有芳香环的新型丙酮衍生物，其制备方法以及作为抗炎药物的含有该衍生物的组合物。本发明的化合物通过各种实验证实具有强效的抗炎活性，例如，通过COX和5-LOX酶活性的抑制试验、LTC复制和NO产生的抑制试验、MTT分析试验、对iNOS和COX-2蛋白表达以及使用RAW 264.7巨噬细胞的PGE复制的抑制试验等。因此，本发明的化合物可用于治疗和预防各种炎症。
• Organic compounds
  申请人：Adcock Claire

  公开号：US20090215776A1

  公开（公告）日：2009-08-27

  Compounds of formula I in free or salt or solvate form, where T 1 , T 2 , X, R a , R b , R 8 and R 9 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

  式I的化合物以自由形式、盐形式或溶剂合形式存在，其中T1、T2、X、Ra、Rb、R8和R9的含义如规范中所示，可用于治疗炎症或阻塞性气道、肺动脉高压、肺纤维化、肝纤维化、肌肉疾病和全身骨骼疾病。还描述了含有这些化合物的药物组合物和制备这些化合物的方法。
• Calcium uptake inhibitors
  申请人：MERRELL PHARMACEUTICALS INC.

  公开号：EP0476646A1

  公开（公告）日：1992-03-25

  This invention relates to 1-aryl-3-pyridinyl-2-propene-1-ones and pharmaceutical compositions containing these compounds as active ingredients useful as calcium uptake inhibitors in leukocytes and thrombocytes and the process of their preparation.

  本发明涉及 1-芳基-3-吡啶基-2-丙烯-1-酮和含有这些化合物作为活性成分的药物组合物，可作为白细胞和血小板的钙摄取抑制剂，及其制备工艺。
• Synthesis, cyclooxygenase inhibition, and anti-inflammatory evaluation of novel diarylheterocycles with a central pyrazole, pyrazoline, or pyridine ring
  作者：Khaled R. A. Abdellatif、Eman K. A. Abdelall、Wael A. A. Fadaly、Gehan M. Kamel

  DOI：10.1007/s00044-015-1327-7

  日期：2015.6

  Five groups of diarylheterocycles with a central pyrazole ring (12a-d), pyrazoline ring (14a-d), or pyridine ring (15a-d, 16a-d and 17a-d) were synthesized and evaluated in vitro for COX-1/COX-2 inhibitory activity and in vivo for anti-inflammatory activity. All compounds that possessed anti-inflammatory activity were assessed for their ulcerogenic liability in comparison with ibuprofen and celecoxib. The pyrazole derivative 12b and the pyrazoline derivative 14b were the least ulcerogenic compounds with relative ulcerogenicities to celecoxib 0.85 and 0.90 respectively.[GRAPHICS].
• PYRIDINE DERIVATIVES
  申请人：Novartis AG

  公开号：EP2242742B1

  公开（公告）日：2015-12-02