4-(4-aminophenyl)-6-chloro-1-(N-pyrrolidino)-3,4-dihydroisoquinoline hydrochloride | 950857-54-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(4-aminophenyl)-6-chloro-1-(N-pyrrolidino)-3,4-dihydroisoquinoline hydrochloride
• 英文别名: 4-(6-Chloro-1-pyrrolidin-1-yl-3,4-dihydroisoquinolin-4-yl)aniline;hydrochloride
• CAS: 950857-54-2
• 化学式: C₁₉H₂₀ClN₃*ClH
• 分子量: 362.302
• InChiKey: KCIHAEVQTDCNHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.33
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  41.6
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM
  申请人：Lang Hans-Jochen

  公开号：US20090118327A1

  公开（公告）日：2009-05-07

  The present invention relates to compounds useful in the prevention or treatment of various disorders such as acute or chronic renal failure, for impairments of biliary function, for respiratory impairments such as snoring or sleep apneas or for stroke, and pharmaceutical compositions comprising them. More specifically, the compounds of the present invention comprises substituted 1-amino-4-phenyl-dihydroisoquinolines and their derivatives of formula I: Wherein the substituents R1-R11 are more specifically defined hereinbelow. The claimed compounds of the present invention also include their pharmaceutically acceptable salts and trifluoroacetates thereof as well as methods for their preparation and pharmaceutical delivery systems thereof.

  本发明涉及用于预防或治疗各种疾病的化合物，如急性或慢性肾衰竭，胆功能障碍，呼吸障碍（如打鼾或睡眠呼吸暂停）或中风，以及包含它们的药物组合物。更具体地，本发明的化合物包括取代的1-氨基-4-苯基-二氢异喹啉及其式I的衍生物：其中取代基R1-R11在下文中更具体地定义。本发明的所述化合物还包括其药用可接受的盐及三氟乙酸盐，以及其制备方法和药物递送系统。
• US8124621B2
  申请人：——

  公开号：US8124621B2

  公开（公告）日：2012-02-28