4-氨基-4-甲基戊-2-炔醛 | 121188-32-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-氨基-4-甲基戊-2-炔醛
• 英文名称: 4-Amino-4-methyl-2-pentyne-1-al
• 英文别名: 4-amino-4-methylpent-2-ynal
• CAS: 121188-32-7
• 化学式: C₆H₉NO
• mdl: MFCD19212307
• 分子量: 111.14
• InChiKey: ZMAIVKIYUIAWSA-UHFFFAOYSA-N

物化性质

• 沸点：
  190.4±23.0 °C(Predicted)
• 密度：
  0.992±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-methyl-4-(2,2,5,5-tetramethyl-1,2,5-azadisilolidin-1-yl)pent-2-ynal 生成 4-氨基-4-甲基戊-2-炔醛
  参考文献：
  名称：

  DOUTHEAU, A.;GORE, J.;QUASH, G.

  摘要：

  DOI：

文献信息

• TREATMENT OF FIBROSIS
  申请人：The University Of Birmingham

  公开号：EP3632420A1

  公开（公告）日：2020-04-08

  The present invention relates an aldehyde dehydrogenase inhibitor for use in the treatment or prevention of fibrosis.

  本发明涉及一种用于治疗或预防纤维化的醛脱氢酶抑制剂。
• Methods and compositions relating to proteasome inhibitor resistance
  申请人：Whitehead Institute for Biomedical Research

  公开号：US11092602B2

  公开（公告）日：2021-08-17

  In some aspects, the disclosure provides methods of modulating the level of proteasome inhibitor resistance of a cell, the methods comprising manipulating the level of expression or activity of a subunit of the 19S proteasome in the cell. In some aspects, cells in which the level of a 19S subunit is modulated, e.g., reduced, are provided. In some aspects, methods of identifying agents that reduce proteasome inhibitor resistance are provided. In some aspects, methods of classifying cancers according to predicted proteasome inhibitor resistance are provided. In some aspects, methods of killing or inhibiting proliferation of cancer cells, e.g., proteasome inhibitor resistant cancer cells, are provided. In some aspects, methods of treating cancer, e.g., proteasome inhibitor resistant cancer, are provided.

  在某些方面，本公开提供了调节细胞蛋白酶体抑制剂抗性水平的方法，这些方法包括操纵细胞中 19S 蛋白酶体亚基的表达水平或活性。在某些方面，提供了 19S 亚基水平被调节（如降低）的细胞。在某些方面，提供了鉴定降低蛋白酶体抑制剂耐药性的制剂的方法。在某些方面，提供了根据预测的蛋白酶体抑制剂耐药性对癌症进行分类的方法。在某些方面，提供了杀死或抑制癌细胞（如蛋白酶体抑制剂抗性癌细胞）增殖的方法。在某些方面，提供了治疗癌症（例如蛋白酶体抑制剂抗性癌症）的方法。
• Methods and Compositions for the Prevention and Treatment of Parasitic Disease
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US20160008419A1

  公开（公告）日：2016-01-14

  Compositions and methods are provided for treating or preventing a parasitic disease in a subject. Aspects of the methods include administering an ALDH antagonist to a subject that is infected with a parasite or that is at risk for being infected with a parasite. Also provided are reagents, devices and kits thereof that find use in practicing the subject methods.
• Treatment of Fibrosis
  申请人：UCL BUSINESS PLC

  公开号：US20170042838A1

  公开（公告）日：2017-02-16

  The present invention relates an aldehyde dehydrogenase inhibitor for use in the treatment or prevention of fibrosis.
• METHODS AND COMPOSITIONS RELATING TO PROTEASOME INHIBITOR RESISTANCE
  申请人：Whitehead Institute for Biomedical Research

  公开号：US20180306796A1

  公开（公告）日：2018-10-25

  In some aspects, the disclosure provides methods of modulating the level of proteasome inhibitor resistance of a cell, the methods comprising manipulating the level of expression or activity of a subunit of the 19S proteasome in the cell. In some aspects, cells in which the level of a 19S subunit is modulated, e.g., reduced, are provided. In some aspects, methods of identifying agents that reduce proteasome inhibitor resistance are provided. In some aspects, methods of classifying cancers according to predicted proteasome inhibitor resistance are provided. In some aspects, methods of killing or inhibiting proliferation of cancer cells, e.g., proteasome inhibitor resistant cancer cells, are provided. In some aspects, methods of treating cancer, e.g., proteasome inhibitor resistant cancer, are provided.