chaetomugilin Q | 1319729-85-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: chaetomugilin Q
• 英文别名: (7S,8S)-5-chloro-7-hydroxy-8-[(3S,4S)-4-hydroxy-3-methyl-2-oxopentyl]-3-[(E,3R,4R)-4-hydroxy-3-methylpent-1-enyl]-7-methyl-8H-isochromen-6-one
• CAS: 1319729-85-5
• 化学式: C₂₂H₂₉ClO₆
• 分子量: 424.922
• InChiKey: VWKWLVNURGSWPO-WGGDPNRLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  chaetomugilin Q 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以20.9%的产率得到chaetomugilin I
  参考文献：
  名称：

  New class azaphilone produced by a marine fish-derived Chaetomium globosum. The stereochemistry and biological activities

  摘要：

  Four new metabolites, chaetomugilins P-R and 11-epi-chaetomugilin I, were isolated from a strain of Chaetomium globosum originally obtained from the marine fish Mugil cephalus, and their absolute stereo-structures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques and various chemical transformations. Particularly, the skeleton of chaetomugilin P is different from that of other azaphilones isolated from this fungal strain to date. In addition, these compounds significantly inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.05.008