H-Thr-Lys(Val)-Pro-Arg-OH | 1056899-70-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Thr-Lys(Val)-Pro-Arg-OH
• 英文别名: H-Thr-Lys(1)-Pro-Arg-OH.H-Val-(1)；(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-6-[[(2S)-2-amino-3-methylbutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
• CAS: 1056899-70-7
• 化学式: C₂₆H₄₉N₉O₇
• 分子量: 599.731
• InChiKey: LLDZHQWLZWGXQJ-HLXURNFRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.3
• 重原子数：
  42
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  282
• 氢给体数：
  9
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  N-Boc-L-缬氨酸 、 Fmoc-L-脯氨酸 、 Fmoc-O-叔丁基-L-苏氨酸 、 Fmoc-Pbf-L-精氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 以62%的产率得到H-Thr-Lys(Val)-Pro-Arg-OH
  参考文献：
  名称：

  Synthesis of linear tuftsin analogues modified at the ε-amino group of lysine

  摘要：

  In this Letter, eight tuftsin analogues, seven of which are novel, are presented. All the linear tuftsin analogues contain an isopeptide bond. Modification of the tuftsin chain was based on the introduction of simple amino acids such as valine, glycine, alanine and beta-alanine into the peptide chain at the epsilon-amino group of lysine. The peptides were synthesized by a solid-phase method using the standard Fmoc procedure. Simultaneous deprotection of the peptide side chain and liberation from the resin was achieved using TFA, and the free novel tuftsin analogues were purified and characterized. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.07.095