| 1235967-66-4

• CAS: 1235967-66-4
• 化学式: C₂₅H₃₁ClO₅Ti
• 分子量: 494.851
• InChiKey: LVYZAKVJQOLMFF-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  氯化亚砜 、 、 丙二酸二乙酯 在 NaH 作用下， 以 neat (no solvent) 、 tetrahydrofuran 、 mineral oil 为溶剂， 以78%的产率得到
  参考文献：
  名称：

  Synthesis of Stable Functional Titanocene Enolates

  摘要：

  A modular approach to bench-stable titanocene enolates is described. The reaction of titanocenes containing pendent acid chlorides activated methylene compounds in the presence of excess base results in the formation the pivotal etiolates. In all cases, the enolates are coordinated to the titanocene, which acts as a stabilizing template in an intramolecular manner, as demonstrated by NMR spectroscopy and X-ray crystallo-graphy. Upon protonation with Strong acids, the C-C bond formed (hiring the acylation is cleaved. Hence, the template effect can be reversed by adjusting the acidity of the reaction medium.

  DOI：

  10.1021/om100245r