Methyl-5-deoxy-α-D-arabinofuranosid | 216660-02-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl-5-deoxy-α-D-arabinofuranosid
• CAS: 216660-02-5
• 化学式: C₆H₁₂O₄
• 分子量: 148.159
• InChiKey: UMFZEEAZPLDBDK-ZXXMMSQZSA-N

反应信息

• 作为反应物：
  描述：

  Methyl-5-deoxy-α-D-arabinofuranosid 、 乙酸酐 在 吡啶 作用下， 反应 18.0h， 以224 mg的产率得到methyl 2,3-di-O-acetyl-5-deoxy-α-D-arabinofuranoside
  参考文献：
  名称：

  硫连接的阿拉伯呋喃糖基二糖的设计、合成和活性对结核分枝杆菌 (MTB) 和鸟分枝杆菌复合体 (MAC)

  摘要：

  我们报告了一系列带有糖苷硫接头的阿拉伯呋喃糖二糖的化学合成，作为阿拉伯呋喃基转移酶受体的模拟物，使用或不使用任何激活剂以避免任何复杂反应。测试了这些类似物对 MTB 菌株 H37Ra 和 3 个 MAC 临床分离株的体外活性。MIC 使用比色微量稀释肉汤测定来确定。杀菌活性是用 7 天的杀菌曲线研究的。在 Mono Mac 6 (MM6) 人单核细胞系中测定了针对 MTB H37Ra 的细胞内活性。

  DOI：

  10.3998/ark.5550190.0014.222
• 作为产物：
  描述：

  methyl 2-O-acetyl-5-deoxy-α-D-arabinofuranoside 在 pig liver esterase sodium hydroxide 作用下， 以 various solvent(s) 为溶剂， 生成 Methyl-5-deoxy-α-D-arabinofuranosid
  参考文献：
  名称：

  Pig Liver Esterase Catalyzed Hydrolysis of Methyl 2,3-Di-O-Acetyl-5-Deoxy-α- and β-D-Arabinofuranosides

  摘要：

  The regioselectivity of a pig liver esterase (PLE) catalyzed hydrolysis of methyl 2,3-di-O-acetyl-5-deoxy-alpha-D-arabinofuranoside (1) and methyl 2,3-di-O-acetyl-5-deoxy-beta-D-arabinofuranoside (2) was established by GLC. Diacetate 1 gave exclusively methyl 3-O-acetyl-5-deoxy-alpha-D-arabinofuranoside while diacetate 2 produced both methyl 2-O-acetyl-5-deoxy-beta-D-arabinofuranoside and methyl 3-O-acetyl-5-deoxy-beta-D-arabinofuranoside which were resistant to subsequent hydrolysis. The Michaelis constants and maximal velocities were determined for 1 and 2. The first-order rate constants were computed for 1, 2, and all corresponding monoacetates. The results were evaluated on the basis of a Jones's active-site model for PLE and the additional criteria valid for acetyl esters of pentofuranosides were proposed.

  DOI：

  10.1080/07328309808001893