[V(maltol(1-))2(dppz)]ClO4 | 1248349-45-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [V(maltol(1-))2(dppz)]ClO4
• 英文别名: [V(III)(maltol(1-))2(dipyrido[3,2-a:2',3'-c]phenazine)](perchlorate)
• CAS: 1248349-45-2
• 化学式: C₃₀H₂₀N₄O₆V*ClO₄
• 分子量: 682.904
• InChiKey: DHPTTYSYNRQVGQ-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  tris(maltolato)vanadium(III) 、 dipyrido[2,3-a:,2',3'-c]phenanzinium perchlorate 以 甲醇 为溶剂， 以93%的产率得到[V(maltol(1-))2(dppz)]ClO4
  参考文献：
  名称：

  Bis(maltolato)vanadium(III)-Polypyridyl Complexes: Synthesis, Characterization, DNA Cleavage, and Insulin Mimetic Activity

  摘要：

  Four vanadium(III) complexes of the general formula [V(ma vertical bar tol)(2)(N-N)]ClO4, where N-N is 2,2'-bipyridine (bpy) (1); 1,10-phenanthroline (phen) (2); dipyrido[3,2-d2',3'-f]quinoxaline (dpq) (3), and dipyrido[3,2-a:2',3'-c]phenazine (dppz) (4), have been synthesized and characterized by IR, UV-visible, NMR spectroscopies, and electrospray ionization mass spectra (ESI-MS). The complexes exhibit the typical H-1 NMR spectra for paramagnetic V(III) species. The structures of complexes 1, 2, and 3 were characterized by single crystal X-ray diffraction. All complexes are monomeric and cationic containing V(III) species ligated to one neutral polypyridyl ligand and two monoanionic bidentate maltolate ligands with a distorted octahedral geometry. The complexes show an irreversible redox peak around +0.80 V versus Ag/AgCl corresponding to one-electron oxidation of V(III) to V(IV). The time-resolved UV visible spectral changes for the complexes during the electrolysis in acetonitrile solution at +1.0 V are consistent with one-electron oxidation of the complexes to yield the stable V(IV) species. All complexes cleave plasmid pBR322 DNA without the addition of any external agents. In vitro insulin mimetic activity against insulin responsive RIN 5f cells indicates that complex 1 has similar activity to insulin while the others have moderate insulin mimetic activity.

  DOI：

  10.1021/ic9025359