5,6,7,8-Tetrahydroquinolin-2-ylmethanamine | 1351972-02-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5,6,7,8-Tetrahydroquinolin-2-ylmethanamine
• CAS: 1351972-02-5
• 化学式: C₁₀H₁₄N₂
• 分子量: 162.23
• InChiKey: OROUBOHYEHBANQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Cathepsin K inhibitors
  申请人：Bamberg Timothy Joe

  公开号：US20070032484A1

  公开（公告）日：2007-02-08

  The present invention provides a compound of the Formula: a pharmaceutically acceptable salt, a solvate, or a prodrug thereof, wherein m, n, Ar 1 , R 1 , R 2 , R 3 , R 4 , and R 5 are those defined herein. The present invention also provides methods for using and preparing compounds of Formula I.

  本发明提供了一种公式的化合物： 其药学上可接受的盐、溶剂合物或前药，其中m、n、Ar 1 、R 1 、R 2 、R 3 、R 4 和R 5 如本文所定义。本发明还提供了使用和制备公式I化合物的方法。
• PROCESS FOR THE DIASTEREOSELECTIVE PREPARATION OF RUTHENIUM COMPLEXES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：US20160046658A1

  公开（公告）日：2016-02-18

  The present invention relates to a process for the preparation of a compound of formula (I), wherein X is —CH 2 —, —CH 2 —CH 2 —, —CH 2 —CH 2 —CH 2 — or —CH 2 —CH 2 —CH 2 —CH 2 —; Y 1 is —CH 2 —; —CH2—CH 2 — or —NH—; Y 2 is NHR 7 , or SH; wherein R 7 is hydrogen, C 1 -C 4 alkyl or phenyl; R— 1 and R 2 , independently from each other, represent aliphatic or aromatic groups; R 3 and R 4 , independently from each other, represent aliphatic or aromatic groups; R 5 and R 6 are each hydrogen or represent together with the carbon atoms to which they are bonded, a phenyl ring; which process comprises reacting a compound of formula II [RuCI 2 (R 8 )n]m (II), wherein n is 1 and m is >1 which represents a polymeric structure if R 8 is a molecule containing two alkene or alkyne moieties coordinating in an hapto-2 coordination mode to the metal; or n is 4 and m is 1 if R 8 is a nitrogen, oxygen or sulfur containing molecule in which said nitrogen, oxygen or sulfur coordinate to the metal; in the presence of an inert solvent which boiling point is from 112° C. to 165° C. with a compound of formula (III), wherein R 5 , R 6 , Y 1 and Y 2 are as defmed under formula I, and a phosphane of formula IV R3R4P—X—PR 1 R 2 (iv), wherein R 1 , R 2 , R 3 , R 4 and X are as defined under formula I.
• NEAR INFRARED ABSORBING COMPOSITION, NEAR INFRARED CUT FILTER, METHOD OF MANUFACTURING NEAR INFRARED CUT FILTER, DEVICE, METHOD OF MANUFACTURING COPPER-CONTAINING POLYMER, AND COPPER-CONTAINING POLYMER
  申请人：FUJIFILM Corporation

  公开号：US20180094086A1

  公开（公告）日：2018-04-05

  The near infrared absorbing composition includes: a copper-containing polymer having a copper complex site at a polymer side chain; and a solvent, in which the copper complex site includes a site multidentate-coordinated to a copper atom and at least one selected from the group consisting of a site monodentate-coordinated to a copper atom and a counter ion to a copper complex skeleton, and a polymer main chain and a copper atom at the copper complex site are bonded to each other through the site monodentate-coordinated to a copper atom or the counter ion.
• US7358373B2
  申请人：——

  公开号：US7358373B2

  公开（公告）日：2008-04-15
• [EN] CATHEPSIN K INHIBITORS<br/>[FR] INHIBITEURS DE LA CATHEPSINE K
  申请人：HOFFMANN LA ROCHE

  公开号：WO2007014839A2

  公开（公告）日：2007-02-08

  [EN] The present invention provides a compound of the Formula (I), a pharmaceutically acceptable salt, a solvate, or a prodrug thereof, wherein m, n, Ar¹, R¹, R², R³, R⁴, and R⁵ are those defined herein. The present invention also provides methods 5 for using and preparing compounds of Formula (I).
  [FR] La présente invention porte sur un composé de formule (I), sur un sel acceptable d'un point de vue pharmaceutique, sur un solvate ou sur un promédicament de celui-ci. Dans cette formule, m, n, Ar¹, R¹, R², R³, R⁴, et R⁵ sont tels que définis dans la demande. La présente invention porte également sur des procédés d'utilisation et de préparation des composés de formule (I).