4-氨基-8-氟-3-喹啉羧酸 | 476683-65-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-氨基-8-氟-3-喹啉羧酸
• 中文别名: 4-氨基-8-氟喹啉-3-羧酸
• 英文名称: 4-Amino-8-fluoro-quinoline-3-carboxylic acid
• 英文别名: 4-Amino-8-fluoroquinoline-3-carboxylic acid
• CAS: 476683-65-5
• 化学式: C₁₀H₇FN₂O₂
• mdl: MFCD10037653
• 分子量: 206.176
• InChiKey: ZAQWDAXYUKQODW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-氨基-8-氟-3-喹啉羧酸 在 盐酸 、 4-(Ph-N=C=N-CH₂CH₂CH₂O-CH₂)C₆H₄-polymer 、 sodium nitrite 作用下， 以 甲苯 为溶剂， 反应 3.75h， 生成 14-Fluoro-8-methyl-2,3,4,8,12-pentazatetracyclo[8.8.0.02,6.013,18]octadeca-1(18),3,5,10,12,14,16-heptaen-9-one
  参考文献：
  名称：

  A concise route to triazolobenzodiazepine derivatives via a one-Pot alkyne-Azide cycloaddition reaction

  摘要：

  A new and efficient one-pot synthesis of [1,2,3]triazolo[1,5-a][1,4] benzodiazepin-6(4H)-ones is described starting from readily available anthranilic acids. A small array of the title compounds were assembled via a four-step sequence involving diazotisation, azide addition followed by amide bond formation employing polymer supported carbodiimide and subsequent 1,3-dipolar cycloaddition reaction. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00262-7

文献信息

• Bone Modulators And Methods Therewith
  申请人：Espina Virginia

  公开号：US20120065166A1

  公开（公告）日：2012-03-15

  THE INVENTION RELATES TO compositions, compounds, proteins and methods of treatment therewith. Aspects of embodiments also relate to a method of treating a patient by delivering to the tissues of said patient or administering to said patient a therapeutically effective amount of one or more compounds. Aspects of embodiments also relate to a method of detecting the presence of bone disease by machine-assaying detectable serotonin. Aspects of embodiments also relate to methods of treating disease in subjects.
• A concise route to triazolobenzodiazepine derivatives via a one-Pot alkyne-Azide cycloaddition reaction
  作者：Andrew W Thomas

  DOI：10.1016/s0960-894x(02)00262-7

  日期：2002.7

  A new and efficient one-pot synthesis of [1,2,3]triazolo[1,5-a][1,4] benzodiazepin-6(4H)-ones is described starting from readily available anthranilic acids. A small array of the title compounds were assembled via a four-step sequence involving diazotisation, azide addition followed by amide bond formation employing polymer supported carbodiimide and subsequent 1,3-dipolar cycloaddition reaction. (C) 2002 Elsevier Science Ltd. All rights reserved.