4-(((1-methyl-4,5-diphenyl-1H-imidazol-2-yl)sulfonyl)methyl)pyridine | 1443114-28-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(((1-methyl-4,5-diphenyl-1H-imidazol-2-yl)sulfonyl)methyl)pyridine
• 英文别名: 4-[(1-Methyl-4,5-diphenylimidazol-2-yl)sulfonylmethyl]pyridine
• CAS: 1443114-28-0
• 化学式: C₂₂H₁₉N₃O₂S
• 分子量: 389.478
• InChiKey: GEXXQZCDTIWEMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  73.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(((4,5-diphenyl-1H-imidazol-2-yl)sulfonyl)methyl)pyridine 、 碘甲烷 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以25%的产率得到4-(((1-methyl-4,5-diphenyl-1H-imidazol-2-yl)sulfonyl)methyl)pyridine
  参考文献：
  名称：

  Synthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy

  摘要：

  Targeting host cell factors required for virus replication provides an alternative to targeting pathogen components and represents a promising approach to develop broad-spectrum antiviral therapeutics. High-throughput screening (HTS) identified two classes of inhibitors (2 and 3) with broad-spectrum antiviral activity against ortho- and paramyxoviruses including influenza A virus (IAV), measles virus (MeV), respiratory syncytial virus (RSV), and human parainfluenza virus type 3 (HPIV3). Hit-to-lead optimization delivered inhibitor 28a, with EC50 values of 0.88 and 0.81 mu M against IAV strain WSN and MeV strain Edmonston, respectively. It was also found that compound 28a delivers good stability in human liver S9 fractions with a half-life of 165 min. These data establish 28a as a promising lead for antiviral therapy through a host-directed mechanism.

  DOI：

  10.1021/ml400166b