1-ethyl-7-hydroxy-5-isobutyl-3,3-dimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione | 1266247-11-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-ethyl-7-hydroxy-5-isobutyl-3,3-dimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione
• 英文别名: 1-Ethyl-7-hydroxy-3,3-dimethyl-5-(2-methylpropyl)-1,5-benzodiazepine-2,4-dione
• CAS: 1266247-11-3
• 化学式: C₁₇H₂₄N₂O₃
• 分子量: 304.389
• InChiKey: RZJNCGQKWOAFEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  60.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PROCESS FOR PRODUCING BENZO[B][1,4]DIAZEPINE-2,4-DIONE COMPOUND
  申请人：Tsujimori Hisayuki

  公开号：US20120149899A1

  公开（公告）日：2012-06-14

  The present invention provides an industrially advantageous, simple, and efficient process for producing a key intermediate of a benzo[b][1,4]diazepine-2,4-dione compound, which is a therapeutic medicine for arrhythmia. The present invention relates to a process for producing a compound represented by formula (1), wherein each of R 1 , R 2 , R 3 and R 4 , which may be the same or different, represents a hydrogen atom or a lower alkyl group, the process including deprotecting a protective group (R 5 ) of a compound represented by formula (2), wherein R 1 , R 2 , R 3 and R 4 are as defined above, and R 5 represents a protective group of a hydroxy group.

  本发明提供了一种在工业上具有优势的、简单而高效的生产苯并[b][1,4]二氮杂环己二酮化合物的关键中间体的方法，该化合物是心律失常的治疗药物。本发明涉及一种生产由式（1）表示的化合物的方法，其中R1、R2、R3和R4中的每一个，可以相同也可以不同，表示氢原子或低碳基团，该方法包括去保护式（R5）的步骤，该保护式是由式（2）表示的化合物的保护基，其中R1、R2、R3和R4如上定义，R5表示羟基的保护基。
• PROCESS FOR PRODUCING BENZO [B] [1,4] DIAZEPINE-2, 4-DIONE COMPOUND
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：US20140194621A1

  公开（公告）日：2014-07-10

  A process for producing a compound represented by formula (1), wherein each of R 1 , R 2 , R 3 and R 4 , which may be the same or different, represents a hydrogen atom or a lower alkyl group, the process includes deprotecting a protective group (R 5 ) of a compound represented by formula (2), wherein R 1 , R 2 , R 3 and R 4 are as defined above, and R 5 represents a protective group of a hydroxy group. The process is an industrially advantageous, simple, and efficient process for producing a key intermediate of a benzo[b][1,4]diazepine-2,4-dione compound, which is a therapeutic medicine for arrhythmia.

  一种生产式（1）所代表的化合物的方法，其中R1、R2、R3和R4，可以相同也可以不同，分别代表氢原子或较低的烷基基团，该方法包括去保护羟基保护基（R5）的步骤，所述保护基化合物的式子为（2），其中R1、R2、R3和R4如上所定义，而R5代表羟基的保护基。该方法是一种工业上有利、简单、高效的方法，用于生产苯并[b][1,4]二氮杂环-2,4-二酮化合物的关键中间体，该化合物是治疗心律不齐的治疗药物。
• US8796447B2
  申请人：——

  公开号：US8796447B2

  公开（公告）日：2014-08-05
• US8940889B2
  申请人：——

  公开号：US8940889B2

  公开（公告）日：2015-01-27