gem-dichlorocyclopropanol | 42039-22-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: gem-dichlorocyclopropanol
• 英文别名: dichlorocyclopropanol；1-Hydroxy-2,2-dichlor-cyclopropan；2,2-Dichlorocyclopropan-1-ol
• CAS: 42039-22-5
• 化学式: C₃H₄Cl₂O
• 分子量: 126.97
• InChiKey: MYGKOTXRVZHQSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  gem-dichlorocyclopropanol 在 二苯并-18-冠醚-6 肼 作用下， 以 乙醇 为溶剂， 以58%的产率得到吡唑
  参考文献：
  名称：

  Preparation of pyrazoles and pyrazolines by the reaction of chlorocyclopropanols with hydrazines in the presence of crown ethers

  摘要：

  DOI：

  10.1007/bf01157367
• 作为产物：
  描述：

  1,1-Dichlor-2-trimethylsiloxy-cyclopropan 在 盐酸 作用下， 以 四氢呋喃 为溶剂， 以100%的产率得到gem-dichlorocyclopropanol
  参考文献：
  名称：

  Inactivation of S-adenosylhomocysteine hydrolase with haloethyl and dihalocyclopropyl esters derived from homoadenosine-6′-carboxylic acid

  摘要：

  In a search for new inhibitors that exploit 5'-6' `hydrolytic activity' of AdoHcy hydrolase, a new series of haloethyl and dihalocyclopropyl esters 2-3 were designed and their interaction with the enzyme studied. Incubation of the enzyme with 2-3 resulted in time- and concentration-dependent inactivation of AdoHcy hydrolase as well as almost total depletion of its NAD+ content. Further results indicated that the `oxidative' but not the `hydrolytic' activity was involved in the inactivation process. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.050

文献信息

• Mechanism-based inactivation of α-chymotrypsin
  作者：Tsuyoshi Ohba、Naoki Tsuchiya、Kuniko Nishimura、Eitatsu Ikeda、Jun Wakayama、Hisashi Takei

  DOI：10.1016/0960-894x(96)00065-0

  日期：1996.3

  The peptidyl ester derivatives of 2,2-dichlorocyclopropanol and the amide derivative of 2,2-dichlorocyclopropylamine were prepred as novel mechanism-based inactivators of alpha-chymotrypsin. The esters inactivated alpha-chymotrypsin irreversibly but the amide did not show any irreversible inhibitory activity toward alpha-chymotrypsin.
• SHOSTAKOVSKIJ, S. M.;MOCHALOV, V. N.;VOROPAEVA, T. K.;SHOSTAKOVSKIJ, V. M+, IZV. AN CCCP. CEP. XIM., 1985, N 1, 231-233
  作者：SHOSTAKOVSKIJ, S. M.、MOCHALOV, V. N.、VOROPAEVA, T. K.、SHOSTAKOVSKIJ, V. M+

  DOI：——

  日期：——