Tf(-2)[Bn(-3)][Bn(-4)][Bn(-6)]a-Man1Me | 95015-28-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Tf(-2)[Bn(-3)][Bn(-4)][Bn(-6)]a-Man1Me
• 英文别名: [(2S,3S,4S,5R,6R)-2-methoxy-4,5-bis(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-3-yl] trifluoromethanesulfonate
• CAS: 95015-28-4
• 化学式: C₂₉H₃₁F₃O₈S
• 分子量: 596.622
• InChiKey: MKFMYAVNRXXNIF-MASCHLQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  41
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  97.9
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  Tf(-2)[Bn(-3)][Bn(-4)][Bn(-6)]a-Man1Me 、 potassium thioacetate 以 N,N-二甲基甲酰胺 为溶剂， 以14%的产率得到
  参考文献：
  名称：

  非糖苷连接的假二糖：硫醚、亚砜、砜、醚、硒醚及其与凝集素的结合

  摘要：

  水解稳定的非糖苷连接的尾对尾假二糖通过远离组成单糖的异头中心的单个桥原子连接。发现一些具有硫桥或氧桥的此类假二糖在与香蕉凝集素和刀豆球蛋白 A 结合时充当二糖模拟物。描述了一种合成此类化合物的小型文库的通用途径。

  DOI：

  10.1002/ejoc.200901481

文献信息

• L-glucose derivatives having fluorescent chromophore
  申请人：HIROSAKI UNIVERSITY

  公开号：US20150212094A1

  公开（公告）日：2015-07-30

  An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities.

  本发明的目的是提供一种准确评估D-葡萄糖特异性进入细胞的方法。本发明的手段是通过将具有荧光色团的D-葡萄糖衍生物与分别具有荧光色团的L-葡萄糖衍生物接触同一细胞系的不同细胞，比较D-葡萄糖衍生物和L-葡萄糖衍生物发出的荧光，通过两种荧光强度之间的差异来评估D-葡萄糖相对于L-葡萄糖特异性地进入细胞。
• METHOD FOR EVALUATING SPECIFIC INCORPORATION OF D-GLUCOSE INTO CELLS
  申请人：Hirosaki University

  公开号：EP2325327A1

  公开（公告）日：2011-05-25

  An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities.

  本发明的目的是提供一种准确评估 D-葡萄糖特异性结合到细胞中的方法。本发明作为实现该目的的方法，其特征在于：将分子中含有荧光发色团并特异性结合到细胞中的 D-葡萄糖衍生物和分子中含有荧光发色团的 L-葡萄糖衍生物分别与待评估的同一细胞株中的不同细胞接触、将分子中含有荧光发色团并特异性结合到细胞中的 D-葡萄糖衍生物发出的荧光与分子中含有荧光发色团的 L-葡萄糖衍生物发出的荧光进行比较，并通过两种荧光强度之间的差值来评估 D-葡萄糖相对于 L-葡萄糖特异性结合到细胞中的情况。
• US8986656B2
  申请人：——

  公开号：US8986656B2

  公开（公告）日：2015-03-24
• US9958450B2
  申请人：——

  公开号：US9958450B2

  公开（公告）日：2018-05-01