allyl (R)-2-(tert-butyldimethylsiloxy)-3-hydroxypropanoate | 848780-57-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: allyl (R)-2-(tert-butyldimethylsiloxy)-3-hydroxypropanoate
• 英文别名: prop-2-enyl (2R)-2-[tert-butyl(dimethyl)silyl]oxy-3-hydroxypropanoate
• CAS: 848780-57-4
• 化学式: C₁₂H₂₄O₄Si
• 分子量: 260.406
• InChiKey: GDHPWUSKLVHAIA-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  55.76
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  allyl (R)-2-(tert-butyldimethylsiloxy)-3-hydroxypropanoate 在 四氮唑 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 生成 (R)-3-(Bis-benzyloxy-phosphoryloxy)-2-(tert-butyl-dimethyl-silanyloxy)-propionic acid allyl ester
  参考文献：
  名称：

  Synthetic studies of the cyclic depsipeptides bearing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit. Total synthesis of the proposed structure of micropeptin T-20

  摘要：

  The first total synthesis of a cyclic depsipeptide possessing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit was successfully IN achieved in a convergent manner by the oxidative construction of the Ahp unit at the later stage of the synthesis. This synthetic work provides data indicating that the structure of the target Ahp-depsipeptide, micropeptin T-20. should be re-examined. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.12.009
• 作为产物：
  描述：

  allyl (R)-2,3-bis(tert-butyldimethylsiloxy)propanoate 在 cerium(III) chloride 、 sodium iodide 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 allyl (R)-2-(tert-butyldimethylsiloxy)-3-hydroxypropanoate
  参考文献：
  名称：

  Synthetic studies of the cyclic depsipeptides bearing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit. Total synthesis of the proposed structure of micropeptin T-20

  摘要：

  The first total synthesis of a cyclic depsipeptide possessing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit was successfully IN achieved in a convergent manner by the oxidative construction of the Ahp unit at the later stage of the synthesis. This synthetic work provides data indicating that the structure of the target Ahp-depsipeptide, micropeptin T-20. should be re-examined. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.12.009