4-氨基-四氢-吡喃-4-羧酸盐酸盐 | 217299-03-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-氨基-四氢-吡喃-4-羧酸盐酸盐
• 中文别名: 4-氨基四氢吡喃-4-羧酸；4-氨基四氢-2H-吡喃-4-羧酸盐酸盐；4-氨基四氢吡喃-4-甲酸
• 英文名称: 4-aminotetrahydro-2H-pyran-4-carboxylic acid hydrochloride
• 英文别名: 4-amino-tetrahydro-pyran-4-carboxylic acid hydrochloride；4-amino-tetrahydropyrane-4-carboxylic acid hydrochloride；4-aminotetrahydropyran-4-carboxylic acid hydrochloride；4-aminooxane-4-carboxylic acid;hydrochloride
• CAS: 217299-03-1
• 化学式: C₆H₁₁NO₃*ClH
• 分子量: 181.619
• InChiKey: ASFXLCNDBDHZGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.0
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  72.6
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2932999099
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

SDS

Name:	4-Amino-4-Carboxytetrahydropyran Hydrochloride 95% Material Safety Data Sheet
Synonym:	None Known
CAS:	217299-03-1

Section 1 - Chemical Product MSDS Name:4-Amino-4-Carboxytetrahydropyran Hydrochloride 95% Material Safety Data Sheet
Synonym:None Known

---

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
217299-03-1	4-Amino-4-Carboxytetrahydropyran Hydro	95%	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

---

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

---

Section 7 - HANDLING and STORAGE
Handling:
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 217299-03-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C6H11NO3.HCl
Molecular Weight: 145.0819

---

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 217299-03-1 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
4-Amino-4-Carboxytetrahydropyran Hydrochloride - Not listed by ACGIH, IARC, or NTP.

---

Section 12 - ECOLOGICAL INFORMATION

---

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 217299-03-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 217299-03-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 217299-03-1 is not listed on the TSCA inventory.
It is for research and development use only.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-氨基-四氢-吡喃-4-羧酸盐酸盐 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 4-氨基四氢-2H-吡喃-4-甲醇
  参考文献：
  名称：

  Quinazoline analogs as receptor tyrosine kinase inhibitors

  摘要：

  这项发明提供了公式I的喹唑啉类似物：其中A与双环环上的5、6、7或8位置的碳之一结合，并且该环被高达两个独立的R3基团取代。该发明还包括将公式I化合物用作I型受体酪氨酸激酶抑制剂以及用于治疗癌症等增殖过度性疾病的方法。

  公开号：

  US20050043334A1

文献信息

• Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform
  作者：Shishir M. Pant、Amanda Mukonoweshuro、Bimbisar Desai、Manoj K. Ramjee、Christopher N. Selway、Gary J. Tarver、Adrian G. Wright、Kristian Birchall、Timothy M. Chapman、Topi A. Tervonen、Juha Klefström

  DOI：10.1021/acs.jmedchem.7b01698

  日期：2018.5.24

  role in hepatocyte growth factor (HGF) signaling and epithelial integrity makes it a target of therapeutic interest in carcinogenesis and metastasis. Using an integrated design, synthesis, and screening platform, we were able to rapidly develop potent and selective inhibitors of hepsin. In progressing from the initial hit 7 to compound 53, the IC50 value against hepsin was improved from ∼1 μM to 22

  肝素是一种膜锚定的丝氨酸蛋白酶，其在肝细胞生长因子（HGF）信号传导和上皮完整性中的作用使其成为癌变和转移的治疗靶标。使用集成的设计，合成和筛选平台，我们能够快速开发出有效的和选择性的肝素抑制剂。从最初的命中7到化合物53的过程中，针对肝素的IC 50值从约1μM提高到22 nM，并且对尿激酶型纤溶酶原激活剂（uPA）的选择性从30倍增加至> 6000倍。随后的体外ADMET分析和细胞研究证实，领先的化合物是用于研究肝素在乳腺肿瘤发生中的作用的有用工具。
• SUBSTITUTED PYRIDOXAZINES
  申请人：Newcom Jason S.

  公开号：US20090247502A1

  公开（公告）日：2009-10-01

  The invention provides compounds having the structure of formula I, and prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof, wherein A, Y and the groups R 1 , R 2 , R 3 and R 4 are defined in the specification. These compounds can be administered in pharmaceutical formulations to modulate cannabinoid receptor activity for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.

  该发明提供具有式I结构的化合物，以及它们的前药、立体异构体、混合物、盐、水合物、溶剂合物、酸盐水合物和同质晶形，其中A、Y以及基团R1、R2、R3和R4在说明书中有定义。这些化合物可以以药物配方形式给予，用于调节大麻素受体活性，预防和治疗各种疾病和症状，包括疼痛、炎症和瘙痒。
• [EN] NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM<br/>[FR] ANTAGONISTES DE BRADYKININE NON-PEPTIDIQUES ET COMPOSITIONS PHARMACEUTIQUES CONSTITUEES DE CES COMPOSES
  申请人：LUSO FARMACO INST

  公开号：WO2006040004A1

  公开（公告）日：2006-04-20

  Non-peptide compounds having activity as selective antagonists of bradykinin (BK) B2 receptor. The compounds are chemically characterized by the presence of an amino acid alpha substituted with a cyclic group and by a tetraalkylammonium group.

  具有作为布雷金肽（BK）B2受体选择性拮抗剂活性的非肽化合物。这些化合物在化学上的特征是存在一个带有环状基团的α-氨基酸取代基和一个四烷基铵基团。
• [EN] QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS<br/>[FR] ANALOGUES DE QUINAZOLINE COMME INHIBITEURS DU RECEPTEUR DE LA TYROSINE KINASE
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2005016346A1

  公开（公告）日：2005-02-24

  This invention provides quinazoline analogs of Formula (I): where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula (I) as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

  本发明提供了公式（I）的喹唑啉类似物，其中A与双环环上的5、6、7或8位置中的至少一个碳原子连接，并且该环被最多两个独立的R3基团取代。本发明还包括使用公式（I）化合物作为I型受体酪氨酸激酶抑制剂和治疗癌症等增生性疾病的方法。
• QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS
  申请人：Wallace Eli

  公开号：US20090048279A1

  公开（公告）日：2009-02-19

  This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R 3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

  本发明提供了公式I的喹唑啉类似物：其中A与双环环上的5、6、7或8位置中的至少一个碳键结合，并且该环被高达两个独立的R3基团取代。本发明还包括使用公式I化合物作为I型受体酪氨酸激酶抑制剂和治疗癌症等增生性疾病的方法。