6,11-O,O-bridged ketone erythromycin A 9-imine acetamide 2'-acetate 3-ketolide | 914369-40-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6,11-O,O-bridged ketone erythromycin A 9-imine acetamide 2'-acetate 3-ketolide
• CAS: 914369-40-7
• 化学式: C₃₆H₅₈N₂O₁₂
• 分子量: 710.863
• InChiKey: MLDKMFQJRLOUFW-WQUKKQPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.69
• 重原子数：
  50.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  176.56
• 氢给体数：
  1.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  6,11-O,O-bridged ketone erythromycin A 9-imine acetamide 2'-acetate 3-ketolide 在 盐酸 、 碳酸氢钠 作用下， 以 乙醇 、 水 、 乙酸乙酯 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Processes for the preparation of 0-(2-aminobenzo[d]oxazol-5-yl)methyl hydroxylamine for the synthesis of 6,11-bicyclic erythromycin derivative EDP-182

  摘要：

  本发明涉及用于制备被称为EDP-182（IX-a）的6-11环式红霉素衍生物的过程和中间体。具体而言，本发明涉及用于制备O-(2-氨基苯并[d]噁唑-5-基)甲基羟胺的过程和中间体。

  公开号：

  US20070207972A1
• 作为产物：
  描述：

  3-Descladinose-6,11-Bridged Ketone Erythromycin A 9-Imine Acetamide 2'-Acetate 在 N-氯代丁二酰亚胺 、 二甲基硫 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.25h， 生成 6,11-O,O-bridged ketone erythromycin A 9-imine acetamide 2'-acetate 3-ketolide
  参考文献：
  名称：

  Processes for the preparation of 0-(2-aminobenzo[d]oxazol-5-yl)methyl hydroxylamine for the synthesis of 6,11-bicyclic erythromycin derivative EDP-182

  摘要：

  本发明涉及用于制备被称为EDP-182（IX-a）的6-11环式红霉素衍生物的过程和中间体。具体而言，本发明涉及用于制备O-(2-氨基苯并[d]噁唑-5-基)甲基羟胺的过程和中间体。

  公开号：

  US20070207972A1

文献信息

• 6-11 Bridged oxime erythromycin derivatives
  申请人：Wang Guoqiang

  公开号：US20060252710A1

  公开（公告）日：2006-11-09

  The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.

  本发明公开了具有以下结构的化合物，或其药学上可接受的盐、酯或前药：这些化合物具有抗菌性能。本发明还涉及包含上述化合物的药物组合物，用于给需要抗生素治疗的受试者。该发明还涉及通过给予包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。该发明还包括制备本发明化合物的方法。
• [EN] PROCESS FOR THE PREPARATION OF T-11 BICYCLIC ERYTHROMYCIN DERIVATIVES<br/>[FR] PROCEDE DE PREPARATION DE DERIVES BICYCLIQUES 6-11 D'ERYTHROMYCINE
  申请人：ENANTA PHARM INC

  公开号：WO2005070918A1

  公开（公告）日：2005-08-04

  The present invention relates to processes and intermediates for the preparation of 6-11 bicyclic erythromycin derivatives. In particular, the presen tinvention relates to processes and intermediates for the preparation of a compound of formula (IX-c).

  本发明涉及用于制备6-11双环红霉素衍生物的过程和中间体。具体而言，本发明涉及用于制备化合物（IX-c）的过程和中间体。
• 6,11-BICYCLOLIDES: BRIDGED BIARYL MACROLIDE DERIVATIVES
  申请人：KIM IN JONG

  公开号：US20090075915A1

  公开（公告）日：2009-03-19

  The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

  本发明揭示了以下化合物的化学式I，或其药学上可接受的盐、酯或前药：这些化合物具有抗菌性能。本发明还涉及包含上述化合物的药物组合物，用于治疗需要抗生素治疗的患者。该发明还涉及通过给予含有本发明化合物的药物组合物来治疗患者的细菌感染的方法。该发明还包括制备本发明化合物的方法。
• 6-11 Bridged Oxime Erythromycin Derivatives
  申请人：Wang Guoqiang

  公开号：US20080262208A1

  公开（公告）日：2008-10-23

  The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.
• 6,11-BRIDGED BIARYL MACROLIDES
  申请人：KIM IN JONG

  公开号：US20090118506A1

  公开（公告）日：2009-05-07

  The present invention discloses compounds of formula I, II or, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.